Effect of an exon 1 mutation in the myostatin gene on the growth traits of the Bian chicken
文献类型： 外文期刊
作者： Zhang, G. X. 1 ; Zhao, X. H. 1 ; Wang, J. Y. 1 ; Ding, F. X. 2 ; Zhang, L. 2 ;
作者机构： 1.Yangzhou Univ, Coll Anim Sci & Technol, Yangzhou 225009, Peoples R China
2.Shanxi Acad Agr Sci, Inst Anim Husb & Vet, Taiyuan 030032, Peoples R China
关键词： chicken;growth traits;myostatin gene;PCR-restriction fragment length polymorphism
期刊名称：ANIMAL GENETICS （ 影响因子：3.169； 五年影响因子：3.058 ）
ISSN： 0268-9146
年卷期： 2012 年 43 卷 4 期
页码：
收录情况： SCI
摘要： Myostatin (MSTN), or growth and differentiation factor 8 (GDF8), is a member of the transforming growth factor (TGF)-beta superfamily. This family functions as a negative regulator of skeletal muscle development and growth in mammals. Single-nucleotide polymorphisms in exon 1 of the Bian chicken myostatin gene were detected by polymerase chain reaction-restriction fragment length polymorphism. A mutation (c.234G>A) in exon 1 was found. Female Bian chickens of genotypes AA and GA had significantly higher body weights than those of genotype GG (P < 0.05 or P < 0.01) from 6 to 18 weeks of age. These results suggested that the mutation c.234G>A in exon 1 could be used as a genetic marker for Bian chicken growth traits.
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