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Protective effect of Momordica charantia water extract against liver injury in restraint-stressed mice and the underlying mechanism

文献类型： 外文期刊

作者： Deng, Yuanyuan 1 ; Tang, Qin 1 ; Zhang, Yan 1 ; Zhang, Ruifen 1 ; Wei, Zhencheng 1 ; Tang, Xiaojun 1 ; Zhang, Mingwei 2 ;

作者机构： 1.Guangdong Acad Agr Sci, Key Lab Funct Foods, Minist Agr, Sericultural & Agri Food Res Inst,Guangdong Key L, Guangzhou, Guangdong, Peoples R China

2.Guangdong Acad Agr Sci, Key Lab Funct Foods, Minist Agr, Sericultural & Agri Food Res Inst,Guangdong Key L, Guangzhou, Guangdong, Peoples R Ch

关键词： Momordica charantia;restraint stress;liver function;antioxidation;mitochondria

期刊名称：FOOD & NUTRITION RESEARCH （ 影响因子：3.894； 五年影响因子：4.442 ）

ISSN： 1654-6628

年卷期： 2017 年 61 卷

页码：

收录情况： SCI

摘要： Background: Momordica charantia is used in China for its jianghuo (heat-clearing and detoxifying) effects. The concept of shanghuo (the antonym of jianghuo, excessive internal heat) in traditional Chinese medicine is considered a type of stress response of the body. The stress process involves internal organs, especially the liver. Objective: We hypothesized that Momordica charantia water extract (MWE) has a hepatoprotective effect and can protect the body from stress. The aim of this study was to investigate the possible effects of MWE against liver injury in restraint-stressed mice. Design: The mice were intragastrically administered with MWE (250, 500 and 750 mg/kg bw) daily for 7 days. The Normal Control (NC) and Model groups were administered distilled water. A positive control group was intragastrically administered vitamin C 250 mg/kg bw. After the last administration, mice were restrained for 20 h. Results: MWE reduced the serum AST and ALT, reduced the NO content and the protein expression level of iNOSin the liver; significantly reduced the mitochondrial ROS content, increased the mitochondrial membrane potential and the activities of mitochondrial respiratory chain complexes I and II in restraint-stressed mice. Conclusions: The results indicate that MWE has a protective effect against liver injury in restraintstressed mice.

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