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Anti-HSV Activity of Kuwanon X from Mulberry Leaves with Genes Expression Inhibitory and HSV-1 Induced NF-kappa B Deactivated Properties

文献类型： 外文期刊

作者： Ma, Fang 1 ; Shen, Wenwei 1 ; Zhang, Xiaoqi 1 ; Li, Manmei 1 ; Wang, Yifei 1 ; Zou, Yuxiao 2 ; Li, Yaolan 1 ; Wang, Hui 3 ;

作者机构： 1.Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Huangpu Da Dao West 601, Guangzhou 510632, Guangdong, Peoples R China

2.Guangdong Acad Agr Sci, Sericultural & Agri Food Res Inst, 133 Yiheng St,Dongguanzhuang RD, Guangzhou 510610, Guangdong, Peoples R China

3.Jinan Univ, Coll Med, Dept Microbiol & Immunol, Huangpu Da Dao West 601, Guangzhou 510632, Guangdong

关键词： anti-herpes simplex virus (HSV) activity;Kuwanon X;penetration;gene expression;nuclear factor (NF)-kappa B;Mulberry

期刊名称：BIOLOGICAL & PHARMACEUTICAL BULLETIN （ 影响因子：2.233； 五年影响因子：2.309 ）

ISSN： 0918-6158

年卷期： 2016 年 39 卷 10 期

页码：

收录情况： SCI

摘要： Six stilbene derivatives isolated from Mulberry leaves including Kuwanon X, Mulberrofuran C, Mulberrofuran G, Moracin C, Moracin M 3'-O-b-glucopyranoside and Moracin M were found to have antiviral effects against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2) at different potencies except for Mulberrofuran G. Kuwanon X exhibited the greatest activity against HSV-1 15577 and clinical strains and HSV-2 strain 333 with IC50 values of 2.2, 1.5 and 2.5 mu g/mL, respectively. Further study revealed that Kuwanon X did not inactivate cell-free HSV-1 particles, but inhibited cellular adsorption and penetration of HSV-1 viral particles. Following viral penetration, Kuwanon X reduced the expression of HSV-1 IE and L genes, and decreased the synthesis of HSV-1 DNA. Furthermore, it was demonstrated that Kuwanon X inhibited the HSV-1-induced nuclear factor (NF)-kappa B activation through blocking the nuclear translocation and DNA binding of NF-kappa B. These results suggest that Kuwanon X exerts anti-HSV activity through multiple modes and could be a potential candidate for the therapy of HSV infection.

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