您好，欢迎访问广东省农业科学院 机构知识库！
广东省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

An association between genetic variation in the roundabout, axon guidance receptor, homolog 2 gene and immunity traits in chickens

文献类型： 外文期刊

作者： Wang, Y. 1 ; Wang, J. 1 ; Li, B. H. 1 ; Qu, H. 1 ; Luo, C. L. 1 ; Shu, D. M. 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Inst Anim Sci, Guangzhou 510640, Guangdong, Peoples R China; State Key Lab Livestock & Poultry Breeding, Guangzhou 510640, Guangdong, Peoples R China

关键词： chicken;roundabout;axon guidance receptor;homolog 2;antibody response to Newcastle disease virus;single nucleotide polymorphism;pyrosequencing technology

期刊名称：POULTRY SCIENCE （ 影响因子：3.352； 五年影响因子：3.679 ）

ISSN： 0032-5791

年卷期： 2014 年 93 卷 1 期

页码：

收录情况： SCI

摘要： The roundabout, axon guidance receptor, homolog 2 (ROBO2) gene is one member of the roundabout (ROBO) family, which belongs to the immunoglobulin superfamily. The ROBO molecules are known to function in axon guidance and cell migration and are involved in SLIT/ROBO signaling. In this study, we obtained the full-length cDNA sequence of the chicken ROBO2 gene. Sequence analysis indicated that 3 SNP (1418G > A, 1421C > A and 2462T > C) exist in exons 5 and 12 of the ROBO2 gene. Genotyping results revealed that the allele frequency of SNP 1421C > A was similar in all tested breeds, but the allele frequencies of the other 2 SNP were different between White Leghorn and Chinese indigenous chickens. Allele G of 1418G > A and allele T of 2462T > C predominated in the Chinese indigenous breed, whereas alleles A and C predominated in the White Leghorn breed. Association analyses revealed that birds with the GG genotype of SNP 1418G > A or the TT genotype of SNP 2462T > C had significantly higher antibody responses to Newcastle disease virus (NDV_S/P; P < 0.01) than carriers of the A allele (GA and AA) or the C allele (TC), respectively. Real-time PCR further revealed that ROBO2 expression in the spleens of the birds with higher antibody responses (GG and TT genotypes at SNP 1418 and 2462, respectively) was significantly higher than in the spleens of birds with the AA and AG genotypes at SNP 1418 or the TC genotype at SNP 2462 (P < 0.01). The results demonstrated that genetic variation at the ROBO2 gene plays a key role in the immune response to Newcastle disease virus, and SNP 1418G > A and 2462T > C can be used as genetic markers for the selection of chickens with stronger immune responses to Newcastle disease virus.

  • 相关文献

[1]A genome-wide association study identifies major loci affecting the immune response against infectious bronchitis virus in chicken. Luo, Chenglong,Qu, Hao,Ma, Jie,Wang, Jie,Shu, Dingming,Hu, Xiaoxiang,Li, Ning,Luo, Chenglong,Qu, Hao,Ma, Jie,Wang, Jie,Shu, Dingming. 2014

[2]Analysis of genetic diversity of the heat shock protein 70 gene on the basis of abundant sequence polymorphisms in chicken breeds. Gan, J. K.,Kong, L. N.,Zhang, X. Q.,Luo, Q. B.,Gan, J. K.,Gan, J. K.,Jiang, L. Y.,Kong, L. N.,Zhang, X. Q.,Luo, Q. B.. 2015

[3]Identification of a potential functional single nucleotide polymorphism for fatness and growth traits in the 3 '-untranslated region of the PCSK1 gene in chickens. Zhang, K.,Cheng, B. H.,Yang, L. L.,Wang, Z. P.,Zhang, H. L.,Xu, S. S.,Wang, S. Z.,Wang, Y. X.,Zhang, H.,Li, H.,Zhang, K.,Cheng, B. H.,Yang, L. L.,Wang, Z. P.,Zhang, H. L.,Xu, S. S.,Wang, S. Z.,Wang, Y. X.,Zhang, H.,Li, H.,Zhang, K.,Cheng, B. H.,Yang, L. L.,Wang, Z. P.,Zhang, H. L.,Xu, S. S.,Wang, S. Z.,Wang, Y. X.,Zhang, H.,Li, H.. 2017

[4]Identification of quantitative trait loci for phosphorus use efficiency traits in rice using a high density SNP map. Wang, Kai,Cui, Kehui,Liu, Guoling,Xie, Weibo,Yu, Huihui,Huang, Jianliang,Nie, Lixiao,Shah, Farooq,Peng, Shaobing,Wang, Kai,Cui, Kehui,Liu, Guoling,Pan, Junfeng,Huang, Jianliang,Nie, Lixiao,Shah, Farooq,Peng, Shaobing,Pan, Junfeng,Shah, Farooq. 2014

[5]Association of eight EST-derived SNPs with carcass and meat quality traits in pigs. Tong, Xiong,Zhang, Zhe,Jiao, Yiren,Xu, Jian,Dang, Hongquyen,Chen, Ye,Jiang, Zhiguo,Duan, Junli,Zhang, Hao,Li, Jiaqi,Wang, Chong.

[6]Association of methionine synthase gene polymorphisms with wool production and quality traits in Chinese Merino population. Rong, E. G.,Zhang, Z. W.,Wang, Z. P.,Yan, X. H.,Li, H.,Wang, N.,Rong, E. G.,Zhang, Z. W.,Wang, Z. P.,Yan, X. H.,Li, H.,Wang, N.,Rong, E. G.,Yang, H..

[7]Polymorphisms in the 5 '-flanking regions of the GH, PRL, and Pit-1 genes with Muscovy duck egg production. Zhang, D. X.,Xu, Z. Q.,Zhang, X. Q.,Zhang, D. X.,He, J.,Ji, C. L.,Zhang, Y..

[8]Deep Sequencing Analysis of miRNA Expression in Breast Muscle of Fast-Growing and Slow-Growing Broilers. Ouyang, Hongjia,He, Xiaomei,Li, Guihuan,Xu, Haiping,Jia, Xinzheng,Nie, Qinghua,Zhang, Xiquan,Ouyang, Hongjia,He, Xiaomei,Li, Guihuan,Xu, Haiping,Jia, Xinzheng,Nie, Qinghua,Zhang, Xiquan,Ouyang, Hongjia,He, Xiaomei,Li, Guihuan,Xu, Haiping,Jia, Xinzheng,Nie, Qinghua,Zhang, Xiquan. 2015

[9]A premature stop codon within the tvb receptor gene results in decreased susceptibility to infection by avian leukosis virus subgroups B, D, and E. Chen, WeiGuo,Liu, Yang,Li, Xinjian,Li, Hongxing,Dai, Zhenkai,Yan, Yiming,Zhang, Xinheng,Lin, Wencheng,Ma, Jingyun,Xie, Qingmei,Chen, WeiGuo,Liu, Yang,Li, Xinjian,Li, Hongxing,Dai, Zhenkai,Yan, Yiming,Zhang, Xinheng,Lin, Wencheng,Ma, Jingyun,Xie, Qingmei,Li, Aijun,Shu, Dingming,Zhang, Huanmin,Chen, WeiGuo,Liu, Yang,Li, Xinjian,Li, Hongxing,Dai, Zhenkai,Yan, Yiming,Zhang, Xinheng,Lin, Wencheng,Ma, Jingyun,Xie, Qingmei,Chen, WeiGuo,Lin, Wencheng,Ma, Jingyun,Xie, Qingmei. 2017

[10]Differential expression of L-FABP and L-BABP between fat and lean chickens. Zhang, Q.,Shi, H.,Liu, W.,Wang, Y.,Wang, Q.,Li, H.,Zhang, Q.,Shi, H.,Liu, W.,Wang, Y.,Li, H.,Wang, Q.. 2013

[11]Differentially expressed genes in the liver of lean and fat chickens. He, Q.,Wang, S. Z.,Leng, L.,Na, W.,Wang, Q. G.,Li, H.,He, Q.,Wang, S. Z.,Leng, L.,Na, W.,Wang, Q. G.,Li, H.,He, Q.,Wang, S. Z.,Leng, L.,Na, W.,Li, H.,Wang, Q. G.. 2014

[12]Biological Characteristics of Chinese Precocious Strain of Eimeria acervulina and Its Immune Efficacy Against Different Field Strains. Wu, Lin-Lin,Lin, Rui-Qing,Duan, Wen-Fang,Zou, Shang-Shu,Yuan, Zi-Guo,Weng, Ya-Biao,Sun, Ming-Fei,Liu, Li-Dan. 2014

[13]Genome-wide association study of antibody response to Newcastle disease virus in chicken. Luo, Chenglong,Qu, Hao,Ma, Jie,Wang, Jie,Li, Chunyu,Yang, Chunfen,Shu, Dingming,Hu, Xiaoxiang,Li, Ning,Luo, Chenglong,Qu, Hao,Ma, Jie,Wang, Jie,Li, Chunyu,Yang, Chunfen,Hu, Xiaoxiang,Shu, Dingming. 2013

[14]Identification of genome-wide SNP-SNP interactions associated with important traits in chicken. Zhang, Hui,Yu, Jia-Qiang,Yang, Li-Li,Zhang, Xin-Yang,Na, Wei,Li, Hui,Zhang, Hui,Yu, Jia-Qiang,Yang, Li-Li,Zhang, Xin-Yang,Na, Wei,Li, Hui,Zhang, Hui,Yu, Jia-Qiang,Yang, Li-Li,Zhang, Xin-Yang,Na, Wei,Li, Hui,Kramer, Luke M.,Reecy, James M.. 2017

[15]Identification and Analysis of a Functional SNP 1196C > A in 3 ' UTR of Chicken IGFBP2 Gene. Yu Ying-Ying,Qiao Shu-Pei,Sun Ying-Ning,Song He,Zhang Xiao-Fei,Yan Xiao-Hong,Li Hui,Wang Ning,Yu Ying-Ying,Qiao Shu-Pei,Sun Ying-Ning,Song He,Zhang Xiao-Fei,Yan Xiao-Hong,Li Hui,Wang Ning,Yu Ying-Ying,Qiao Shu-Pei,Sun Ying-Ning,Song He,Zhang Xiao-Fei,Yan Xiao-Hong,Li Hui,Wang Ning,Sun Ying-Ning. 2014

[16]Let-7b Regulates Myoblast Proliferation by Inhibiting IGF2BP3 Expression in Dwarf and Normal Chicken. Lin, Shumao,Luo, Wen,Bekele, Endashaw J.,Nie, Qinghua,Zhang, Xiquan,Lin, Shumao,Luo, Wen,Bekele, Endashaw J.,Nie, Qinghua,Zhang, Xiquan,Lin, Shumao,Luo, Wen,Bekele, Endashaw J.,Nie, Qinghua,Zhang, Xiquan,Lin, Shumao,Ye, Yaqiong,Ye, Yaqiong,Li, Yugu. 2017

[17]Copy Number Variation in SOX6 Contributes to Chicken Muscle Development. Lin, Shudai,Lin, Xiran,Zhang, Zihao,Jiang, Mingya,Nie, Qinghua,Zhang, Xiquan,Rao, Yousheng. 2018

[18]Detection of genome-wide copy number variations in two chicken lines divergently selected for abdominal fat content. Zhang, Hui,Du, Zhi-Qiang,Dong, Jia-Qiang,Wang, Hai-Xia,Shi, Hong-Yan,Wang, Ning,Wang, Shou-Zhi,Li, Hui,Zhang, Hui,Du, Zhi-Qiang,Dong, Jia-Qiang,Wang, Hai-Xia,Shi, Hong-Yan,Wang, Ning,Wang, Shou-Zhi,Li, Hui,Zhang, Hui,Du, Zhi-Qiang,Dong, Jia-Qiang,Wang, Hai-Xia,Shi, Hong-Yan,Wang, Ning,Wang, Shou-Zhi,Li, Hui. 2014

[19]Construction of multiple linear regression models using blood biomarkers for selecting against abdominal fat traits in broilers. Dong, J. Q.,Zhang, X. Y.,Wang, S. Z.,Zhang, K.,Ma, G. W.,Wu, M. Q.,Li, H.,Zhang, H.,Dong, J. Q.,Zhang, X. Y.,Wang, S. Z.,Zhang, K.,Ma, G. W.,Wu, M. Q.,Li, H.,Zhang, H.,Dong, J. Q.,Zhang, X. Y.,Wang, S. Z.,Zhang, K.,Ma, G. W.,Wu, M. Q.,Li, H.,Zhang, H.,Dong, J. Q.,Jiang, X. F.. 2018

[20]Integrated Analysis of Long Non-coding RNAs (LncRNAs) and mRNA Expression Profiles Reveals the Potential Role of LncRNAs in Skeletal Muscle Development of the Chicken. Li, Zhenhui,Ouyang, Hongjia,Zheng, Ming,Cai, Bolin,Han, Peigong,Abdalla, Bahareldin A.,Nie, Qinghua,Zhang, Xiquan,Li, Zhenhui,Ouyang, Hongjia,Zheng, Ming,Cai, Bolin,Han, Peigong,Abdalla, Bahareldin A.,Nie, Qinghua,Zhang, Xiquan,Li, Zhenhui,Ouyang, Hongjia,Zheng, Ming,Cai, Bolin,Han, Peigong,Abdalla, Bahareldin A.,Nie, Qinghua,Zhang, Xiquan. 2017

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：广东省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台