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Genome-Wide Association Study Identified a Narrow Chromosome 1 Region Associated with Chicken Growth Traits

文献类型： 外文期刊

作者： Xie, Liang 1 ; Luo, Chenglong 1 ; Zhang, Chengguang 1 ; Zhang, Rong 1 ; Tang, Jun 1 ; Nie, Qinghua 1 ; Ma, Li 2 ; Hu, Xia 1 ;

作者机构： 1.Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou, Guangdong, Peoples R China

2.Univ Minnesota, Dept Anim Sci, St Paul, MN 55108 USA

3.State Key Lab Livestock & Poultry Breeding, Guangzhou, Guangdong, Peoples R China

4.Hainan Acad Agr Sci, Inst Anim Sci & Vet, Haikou, Hainan, Peoples R China

5.China Agr Univ, Coll Biol Sci, Beijing 100094, Peoples R China

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2012 年 7 卷 2 期

页码：

收录情况： SCI

摘要： Chicken growth traits are important economic traits in broilers. A large number of studies are available on finding genetic factors affecting chicken growth. However, most of these studies identified chromosome regions containing putative quantitative trait loci and finding causal mutations is still a challenge. In this genome-wide association study (GWAS), we identified a narrow 1.5 Mb region (173.5-175 Mb) of chicken (Gallus gallus) chromosome (GGA) 1 to be strongly associated with chicken growth using 47,678 SNPs and 489 F2 chickens. The growth traits included aggregate body weight (BW) at 0-90 d of age measured weekly, biweekly average daily gains (ADG) derived from weekly body weight, and breast muscle weight (BMW), leg muscle weight (LMW) and wing weight (WW) at 90 d of age. Five SNPs in the 1.5 Mb KPNA3-FOXO1A region at GGA1 had the highest significant effects for all growth traits in this study, including a SNP at 8.9 Kb upstream of FOXO1A for BW at 22-48 d and 70 d, a SNP at 1.9 Kb downstream of FOXO1A for WW, a SNP at 20.9 Kb downstream of ENSGALG00000022732 for ADG at 29-42 d, a SNP in INTS6 for BW at 90 d, and a SNP in KPNA3 for BMW and LMW. The 1.5 Mb KPNA3-FOXO1A region contained two microRNA genes that could bind to messenger ribonucleic acid (mRNA) of IGF1, FOXO1A and KPNA3. It was further indicated that the 1.5 Mb GGA1 region had the strongest effects on chicken growth during 22-42 d.

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