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Antioxidant and Anticancer Activities of Wampee (Clausena lansium (Lour.) Skeels) Peel

文献类型： 外文期刊

作者： Prasad, K. Nagendra 3 ; Hao, Jing 3 ; Yi, Chun 3 ; Zhang, Dandan 3 ; Qiu, Shengxiang 3 ; Jiang, Yueming 3 ; Zhang, Min 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Biotechnol Res Inst, Guangzhou 510610, Guangdong, Peoples R China

2.Clemson Univ, Dept Food Sci & Human Nutr, Clemson, SC 29634 USA

3.Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, S China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China

期刊名称：JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY （ 影响因子：3.169； 五年影响因子：3.132 ）

ISSN： 1110-7243

年卷期： 2009 年

页码：

收录情况： SCI

摘要： Antioxidant activities of wampee peel extracts using five different solvents (ethanol, hexane, ethyl acetate, butanol and water) were determined by using in-vitro antioxidant models including total antioxidant capability, 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity, reducing power, and superoxide scavenging activity. Ethyl acetate fraction (EAF) exhibited the highest antioxidant activity compared to other fractions, even higher than synthetic antioxidant butylated hydroxyl toluene (BHT). In addition, the EAF exhibited strong anticancer activities against human gastric carcinoma (SGC-7901), human hepatocellular liver carcinoma (HepG-2) and human lung adenocarcinoma (A-549) cancer cell lines, higher than cisplatin, a conventional anticancer drug. The total phenolic content of wampee fraction was positively correlated with the antioxidant activity. This is the first report on the antioxidant and anticancer activities of the wampee peel extract. Thus, wampee peel can be used potentially as a readily accessible source of natural antioxidants and a possible pharmaceutical supplement. Copyright (C) 2009 K. Nagendra Prasad et al.

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