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Effect of transgenic expression of porcine interleukin-6 gene and CpG sequences on immune responses of newborn piglets inoculated with Pseudorabies attenuated vaccine

文献类型: 外文期刊

作者: Zhang, LH 1 ; Tian, XS 2 ; Guo, Y 2 ; Zhou, FZ 2 ; Meng, MJ 3 ;

作者机构: 1.Guangdong Acad Agr Sci, Biotech Res Inst, Guangzhou 510640, Peoples R China

2.Guangdong Acad Agr Sci, Biotech Res Inst, Guangzhou 510640, Peoples R China; S China Univ Technol, Sch Biosci & Bioengn, Guangzhou 510640, Peoples R China; GuangDong Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Guangzhou 510224, Peoples R China

3.Guangdong Acad Agr Sci, Biotech Res Inst, Guangzhou 510640, Peoples R China; S China Univ Technol, Sch Biosci & Bioengn, Guangzhou 510640, Peoples R China; GuangDong Pharmaceut Univ, Sch Life Sci & Bioph

关键词: newborn piglets;pseudorabies attenuated vaccine;CpG motifs;immune response;interleukin-6

期刊名称:RESEARCH IN VETERINARY SCIENCE ( 影响因子:2.534; 五年影响因子:2.382 )

ISSN: 0034-5288

年卷期: 2006 年 80 卷 3 期

页码:

收录情况: SCI

摘要: Porcine interleukin-6 gene and CpG sequences were used as immunoadjuvants to enhance the immune responses of newborn piglets to Pseudorabies attenuated vaccine (PAV). The titer of specific antibodies to PAV, the proliferation of lymphocytes and induced IL-2 activities were all examined to identify the immune response of the piglets. The results showed that the immune responses with CpG ODN and porcine interleukin-6 gene were significantly stronger than routine immunities. The data suggests that porcine IL-6 and CpG motifs could be employed as effective immunoadjuvants to raise the humoral and cellular responses of newborn piglets to Pseudorabies attenuated vaccine. (c) 2005 Elsevier Ltd. All rights reserved.

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