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Integrative Analysis of the Microbiome and Metabolome of Broiler Intestine: Insights into the Mechanisms of Probiotic Action as an Antibiotic Substitute

文献类型： 外文期刊

作者： Li, Yang 1 ; Zhang, Jian-Ling 2 ; Chen, Jia-Qi 5 ; Chen, Zhuang 1 ; Liu, Shi 1 ; Liu, Jing 1 ; Huang, Wen-Jie 1 ; Li, Jia-Zhou 3 ; Ruan, Dong 4 ; Deng, Jun-Jin 1 ; Wang, Zhi-Lin 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Agrobiol Gene Res Ctr, State Key Lab Livestock & Poultry Breeding, 20 Jinying Rd, Guangzhou 510640, Guangdong, Peoples R China

2.Jiangmen Customs Technol Ctr, Jiangmen 529085, Peoples R China

3.Ling Nan Modern Agr Sci & Technol Guangdong Prov L, He Yuan Branch, Heyuan 517500, Peoples R China

4.Guangdong Acad Agr Sci, Inst Anim Sci, Minist Agr & Rural Affairs, Guangdong Key Lab Anim Breeding & Nutr,Key Lab Ani, 1 Dafeng St,Wushan Rd, Guangzhou 510640, Guangdong, Peoples R China

5.Guangdong Polytech Sci & Trade, Coll Landscape Architecture, Guangzhou 510640, Guangdong, Peoples R China

关键词： Broiler breeding; Antibiotic substitute; Growth performance; Microbiome; Metabolome

期刊名称：PROBIOTICS AND ANTIMICROBIAL PROTEINS （ 影响因子：4.4； 五年影响因子：5.0 ）

ISSN： 1867-1306

年卷期： 2024 年

页码：

收录情况： SCI

摘要： Antibiotic substitutes have become a research focus due to restrictions on antibiotic usage. Among the antibiotic substitutes on the market, probiotics have been extensively researched and used. However, the mechanism by which probiotics replace antibiotics remains unclear. In this study, we aimed to investigate this mechanism by comparing the effects of probiotics and antibiotics on broiler growth performance and intestinal microbiota composition. Results shown that both probiotics and antibiotics increased daily weight gain and reduced feed conversion rate in broilers. Analysis of ileum and cecum microorganisms via 16S rRNA gene sequencing revealed that both interventions decreased intestinal microbial diversity. Moreover, the abundance of Bacteroides increased in the mature ileum, while that of Erysipelatoclostridium decreased in the cecum in response to both probiotics and antibiotics. The main metabolites of probiotics and antibiotics in the intestine were found to be organic acids, amino acids, and sugars, which might play comparable roles in growth performance. Furthermore, disaccharides and trisaccharides may be essential components in the ileum that enable probiotics to replace antibiotics. These findings provide important insights into the mechanisms underlying the use of probiotics as antibiotic substitutes in broiler breeding.

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