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Malvidin and its Glycosides from Vaccinium ashei Improve Endothelial Function by Anti-inflammatory and Angiotensin I-Converting Enzyme Inhibitory Effects

文献类型： 外文期刊

作者： Huang, Wu-Yang 1 ; Wang, Xing-Na 1 ; Wang, Jing 2 ; Sui, Zhong-Quan 3 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Farm Prod Proc, Nanjing 210014, Jiangsu, Peoples R China

2.Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Jiangsu, Peoples R China

3.Shanghai Jiao Tong Univ, Sch Agr & Biol, Dept Food Sci & Engn, Shanghai 200240, Peoples R China

关键词： Blueberry;Malvidin and glycosides;Anti-inflammation;ACE inhibitor;Endothelial cells

期刊名称：NATURAL PRODUCT COMMUNICATIONS （ 影响因子：0.986； 五年影响因子：1.068 ）

ISSN： 1934-578X

年卷期： 2018 年 13 卷 1 期

页码：

收录情况： SCI

摘要： Protective effects of malvidin and the glycosides from Vaccinium ashei on endothelial cells were investigated. The results showed that malvidin, malvidin-3-glucoside, malvidin-3-galactoside, and their mixture could defend endothelial cells from damage caused by TNF-alpha, and inhibit monocyte chemotactic protein 1, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and angiotensin I-converting enzyme expression. In addition, they could inhibit degradation of I kappa B alpha and obstruct the nuclear translocation of p65, suggesting the anti-inflammatory mechanism of NF-kappa B pathway. The results indicated blueberry anthocyanins could be potential inflammation and ACE inhibitors, and blueberry could be functional foods advantageous to maintain a healthy cardiovascular population.

  • 相关文献

[1]Inhibitory effect of Malvidin on TNF-alpha-induced inflammatory response in endothelial cells. Huang, Wu-Yang,Wang, Jian,Li, Chun-Yang,Wang, Jian,Liu, Ya-Mei,Zheng, Qi-Sheng. 2014

[2]Quercetin, Hyperin, and Chlorogenic Acid Improve Endothelial Function by Antioxidant, Antiinflammatory, and ACE Inhibitory Effects. Huang, Wu-Yang,Fu, Lin,Li, Chun-Yang,Huang, Wu-Yang,Fu, Lin,Xu, Li-Ping.

[3]Promotion of atherosclerosis in high cholesterol diet-fed rabbits by immunization with the P277 peptide. Xiong, Qiyan,Feng, Jiao,Zhang, Yu,Sun, Yunxiao,Lu, Yong,Li, Taiming,Cao, Rongyue,Jin, Liang,Wu, Jie,Xiong, Qiyan,Feng, Jiao,Jin, Liang,Zhang, Xiaohong.

[4]Antihypertensive activity of Rosa rugosa Thunb. flowers: Angiotensin I converting enzyme inhibitor. Xie, Yajing,Zhang, Wei,Xie, Yajing. 2012

[5]Bioactive Natural Constituents from Food Sources - Potential Use in Hypertension Prevention and Treatment. Huang, Wu-Yang,Huang, Wu-Yang,Wu, Jianping,Davidge, Sandra T.. 2013

[6]Egg-Derived Peptide IRW Inhibits TNF-alpha-Induced Inflammatory Response and Oxidative Stress in Endothelial Cells. Chakrabarti, Subhadeep,Jiang, Yanyan,Davidge, Sandra T.,Chakrabarti, Subhadeep,Jiang, Yanyan,Davidge, Sandra T.,Chakrabarti, Subhadeep,Jiang, Yanyan,Davidge, Sandra T.,Huang, Wuyang,Majumder, Kaustav,Wu, Jianping,Huang, Wuyang. 2010

[7]Anti-Inflammatory Effect of the Blueberry Anthocyanins Malvidin-3-Glucoside and Malvidin-3-Galactoside in Endothelial Cells. Huang, Wu-Yang,Wang, Jian,Wang, Xing-Na,Li, Chun-Yang,Liu, Ya-Mei,Wang, Jian.

[8]Composition of Polyphenols and Antioxidant Activity of Rabbiteye Blueberry (Vaccinium ashei) in Nanjing. Li, Chunyang,Feng, Jin,Huang, Wu-Yang,An, Xiao-Ting,Feng, Jin.

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