Malvidin and its Glycosides from Vaccinium ashei Improve Endothelial Function by Anti-inflammatory and Angiotensin I-Converting Enzyme Inhibitory Effects
文献类型: 外文期刊
作者: Huang, Wu-Yang 1 ; Wang, Xing-Na 1 ; Wang, Jing 2 ; Sui, Zhong-Quan 3 ;
作者机构: 1.Jiangsu Acad Agr Sci, Inst Farm Prod Proc, Nanjing 210014, Jiangsu, Peoples R China
2.Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Jiangsu, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Agr & Biol, Dept Food Sci & Engn, Shanghai 200240, Peoples R China
关键词: Blueberry;Malvidin and glycosides;Anti-inflammation;ACE inhibitor;Endothelial cells
期刊名称:NATURAL PRODUCT COMMUNICATIONS ( 影响因子:0.986; 五年影响因子:1.068 )
ISSN: 1934-578X
年卷期: 2018 年 13 卷 1 期
页码:
收录情况: SCI
摘要: Protective effects of malvidin and the glycosides from Vaccinium ashei on endothelial cells were investigated. The results showed that malvidin, malvidin-3-glucoside, malvidin-3-galactoside, and their mixture could defend endothelial cells from damage caused by TNF-alpha, and inhibit monocyte chemotactic protein 1, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and angiotensin I-converting enzyme expression. In addition, they could inhibit degradation of I kappa B alpha and obstruct the nuclear translocation of p65, suggesting the anti-inflammatory mechanism of NF-kappa B pathway. The results indicated blueberry anthocyanins could be potential inflammation and ACE inhibitors, and blueberry could be functional foods advantageous to maintain a healthy cardiovascular population.
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