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The C-terminal region of the Turnip mosaic virus P3 protein is essential for viral infection via targeting P3 to the viral replication complex

文献类型： 外文期刊

作者： Cui, Xiaoyan 1 ; Yaghmaiean, Hoda 2 ; Wu, Guanwei 1 ; Wu, Xiaoyan 2 ; Chen, Xin 1 ; Thorn, Greg 3 ; Wang, Aiming 2 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Vegetable Crops, Nanjing 210014, Jiangsu, Peoples R China

2.Agr & Agri Food Canada, London Res & Dev Ctr, London, ON N5V 4T3, Canada

3.Western Univ, Dept Biol, London, ON N6A 5B7, Canada

4.Zhejiang A&F Univ, Coll Agr & Food Sci, Linen 311300, Zhejiang, Peoples R China

5.Univ British Columbia, Dept Bot, 3200-6270 Univ Bl

关键词： Plant RNA virus;Potyvirus;Turnip mosaic virus;P3;P3N-PIPO;Movement protein;Cell-to-cell movement;Punctate inclusion;Virus replication complex

期刊名称：VIROLOGY （ 影响因子：3.616； 五年影响因子：3.967 ）

ISSN： 0042-6822

年卷期： 2017 年 510 卷

页码：

收录情况： SCI

摘要： Like other positive-strand RNA viruses, plant potyviruses assemble viral replication complexes (VRCs) on modified cellular membranes. Potyviruses encode two membrane proteins, 6K2 and P3. The former is known to play pivotal roles in the formation of membrane-associated VRCs. However, P3 remains to be one of the least characterized potyviral proteins. The P3 cistron codes for P3 as well as P3N-PIPO which results from RNA polymerase slippage. In this study, we show that the P3N-PIPO of Turnip mosaic virus (TuMV) is required for viral cell-to-cell movement but not for viral replication. We demonstrate that the C-terminal region of P3 (P3C) is indispensable for P3 to form cytoplasmic punctate inclusions and target VRCs. We reveal that TuMV mutants that lack P3C are replication-defective. Taken together, these data suggest that the P3 cistron has two distinct functions: P3N-PIPO as a dedicated movement protein and P3 as an essential component of the VRC.

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[1]Identification for soybean host factors interacting with P3N-PIPO protein of Soybean mosaic virus. Song, Puwen,Gao, Le,Zhi, Haijian,Chen, Xin,Wu, Bingyue,Cui, Xiaoyan.

[2]Soybean Golgi SNARE 12 protein interacts with Soybean mosaic virus encoded P3N-PIPO protein. Song, Puwen,Wu, Bingyue,Cui, Xiaoyan,Chen, Xin,Zhi, Haijian.

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[4]The interaction of soybean reticulon homology domain protein (GmRHP) with Soybean mosaic virus encoded P3 contributes to the viral infection. Cui, Xiaoyan,Lu, Lu,Wang, Ying,Yuan, Xingxing,Chen, Xin,Wang, Ying. 2018

[5]Soybean actin-depolymerizing factor 2 interacts with Soybean mosaic virus-encoded P3 protein. Lu, Lu,Xu, Xiaoming,Luan, Hexiang,Zhi, Haijian,Cui, Jin,Lu, Lu,Wu, Guanwei,Cui, Xiaoyan,Chen, Xin.

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