您好，欢迎访问江苏省农业科学院 机构知识库！
江苏省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Antioxidant and Anti-aging Activities of &ITSilybum Marianum&IT Protein Hydrolysate in Mice Treated with D-galactose

文献类型： 外文期刊

作者： Zhu Shu Yun 1 ; Jiang Ning 3 ; Tu Jie 4 ; Yang Jing 1 ; Zhou Yue 1 ;

作者机构： 1.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China

2.Jiangsu Hengshun Grp Co Ltd, Zhenjiang 212000, Jiangsu, Peoples R China

3.Jiangsu Acad Agr Sci, Inst Vegetables, Nanjing 210014, Jiangsu, Peoples R China

4.Jiangsu Univ Sci & Technol, Coll Biotechnol, Zhenjiang 212018, Jiangsu, Peoples R China

关键词： Silybum marianum protein hydrolysate;Antioxidant;Anti-aging;D-galactose

期刊名称：BIOMEDICAL AND ENVIRONMENTAL SCIENCES （ 影响因子：3.118； 五年影响因子：3.219 ）

ISSN： 0895-3988

年卷期： 2017 年 30 卷 9 期

页码：

收录情况： SCI

摘要： Objective In the present study, we investigated the antioxidant and anti-aging effects of Silybum marianum protein hydrolysate (SMPH) in D-galactose-treated mice.& para;& para;Methods D-galactose (500 mg/kg body weight) was intraperitoneally injected daily for 7 weeks to accelerate aging, and SMPH (400, 800, 1,200 mg/kg body weight, respectively) was simultaneously administered orally. The antioxidant and anti-aging effects of SMPH in the liver and brain were measured by biochemical assays. Transmission electron microscopy (TEM) was performed to study the ultrastructure of liver mitochondria.& para;& para;Results SMPH decreased triglyceride and cholesterol levels in the D-galactose-treated mice. It significantly elevated the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and total antioxidant capacity (T-AOC), which were suppressed by D-galactose. Monoamine oxidase (MAO) and malondialdehyde (MDA) levels as well as the concentrations of caspase-3 and 8-OHdG in the liver and brain were significantly reduced by SMPH. Moreover, it increased Bcl-2 levels in the liver and brain. Furthermore, SMPH significantly attenuated D-galactose-induced liver mitochondrial dysfunction by improving the activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase as well as mitochondrial membrane potential (AWm) and fluidity. TEM showed that the degree of liver mitochondrial damage was significantly decreased by SMPH.& para;& para;Conclusion The results indicated that SMPH protects against D-galactose-induced accelerated aging in mice through its antioxidant and anti-aging activities.

  • 相关文献

[1]Protective Effects of Blueberry Anthocyanins against H2O2-Induced Oxidative Injuries in Human Retinal Pigment Epithelial Cells. Huang, Wu-Yang,Wu, Han,Li, Da-Jing,Song, Jiang-Feng,Xiao, Ya-Dong,Liu, Chun-Quan,Zhou, Jian-Zhong,Huang, Wu-Yang,Sui, Zhong-Quan. 2018

[2]Egg-Derived Peptide IRW Inhibits TNF-alpha-Induced Inflammatory Response and Oxidative Stress in Endothelial Cells. Chakrabarti, Subhadeep,Jiang, Yanyan,Davidge, Sandra T.,Chakrabarti, Subhadeep,Jiang, Yanyan,Davidge, Sandra T.,Chakrabarti, Subhadeep,Jiang, Yanyan,Davidge, Sandra T.,Huang, Wuyang,Majumder, Kaustav,Wu, Jianping,Huang, Wuyang. 2010

[3]Antihyperlipidaemic and hepatoprotective activities of acidic and enzymatic hydrolysis exopolysaccharides from Pleurotus eryngii SI-04. Gong, Zhiyuan,Zhang, Chen,Song, Xingling,Zhang, Jianjun,Jia, Le,Li, Juan,Wang, Jing,Wu, Shang,Hu, Chunlong. 2017

[4]Chemical composition, antioxidant and cytoprotective activities of lotus receptacle. Shen, Ting,Wang, Xinfeng,Wu, Lei,Ji, Lilian,Hu, Weicheng,Shen, Ting,Wang, Xinfeng,Wu, Lei,Ji, Lilian,Wang, Gongcheng,Wang, Yuning,Li, Pengxia,Hu, Boran. 2015

[5]Genotypic differences in the antioxidant and carbon-nitrogen metabolism of acid-tolerant and acid-sensitive rice (Oryzasativa L.) cultivars under acid stress. Tang, Shuanhu,Yang, Shaohai,Huang, Xu,Huang, Qiaoyi,Zhang, Mu,Tang, Shuanhu,Yang, Shaohai,Huang, Xu,Huang, Qiaoyi,Zhang, Mu,Tang, Shuanhu,Yang, Shaohai,Huang, Xu,Huang, Qiaoyi.

[6]Effect of Cooking Methods on Total Phenolic and Carotenoid Amounts and DPPH Radical Scavenging Activity of Fresh and Frozen Sweet Corn (Zea mays) Kernels. Song, Jiangfeng,Liu, Chunquan,Li, Dajing,Meng, Lili.

[7]Research Progress in Structure-Activity Relationship of Bioactive Peptides. Li, Ying,Yu, Jianmei,Li, Ying.

[8]Quercetin, Hyperin, and Chlorogenic Acid Improve Endothelial Function by Antioxidant, Antiinflammatory, and ACE Inhibitory Effects. Huang, Wu-Yang,Fu, Lin,Li, Chun-Yang,Huang, Wu-Yang,Fu, Lin,Xu, Li-Ping.

[9]Polyphenol Profiles and Antioxidant Properties of Ethanol Extracts from Osmanthus Fragrans (Thunb.) Lour. Flowers. Li, Hong-Ling,Chai, Zhi,Li, Chun-Yang,Li, Hong-Ling,Li, Chun-Yang,Shen, Garry X.,Shen, Garry X..

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：江苏省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台