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Microplastics interact with SARS-CoV-2 and facilitate host cell infection

文献类型： 外文期刊

作者： Zhang, Guofang 1 ; Cao, Guoli 1 ; Luo, Rong-Hua 4 ; Song, Qingle 1 ; Zeng, Yanqiao 1 ; Liu, Ke 5 ; Qu, Jing 6 ; Lin, Xian 5 ; Liu, Feng-Liang 4 ; Wang, Guocheng 7 ; Li, Hongchang 5 ; Li, Liang 6 ; Zheng, Yong-Tang 4 ; Boraschi, Diana 1 ; Wu, Lidong 8 ; Chang, Yan-Zhong 3 ; Li, Yang 1 ;

作者机构： 1.Chinese Acad Sci, Lab Immunol & Nanomed, Shenzhen 518055, Peoples R China

2.Chinese Acad Sci, China Italy Joint Lab Pharmacobiotechnol Med Immu, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China

3.Hebei Normal Univ, Coll Life Sci, Lab Mol Iron Metab, Shijiazhuang 050016, Hebei, Peoples R China

4.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming Inst Zool, Kunming 650201, Yunnan, Peoples R China

5.Chinese Acad Sci, Shenzhen Inst Adv Technol, Guangdong Key Lab Nanomed, Shenzhen 518055, Peoples R China

6.Chinese Acad Sci, Ctr Energy Metab & Reprod, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China

7.Chinese Acad Sci, Ctr Human Tissues & Organs Degenerat, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China

8.Chinese Acad Fishery Sci, Key Lab Control Aquat Prod Qual & Safety, Minist Agr & Rural Affairs, Beijing 100141, Peoples R China

期刊名称：ENVIRONMENTAL SCIENCE-NANO （ 影响因子：9.473； 五年影响因子：9.35 ）

ISSN： 2051-8153

年卷期： 2022 年 9 卷 8 期

页码：

收录情况： SCI

摘要： Microplastics (MP) pollution is a global issue that raises concerns about potential toxicity for environmental and human health. The notion that SARS-CoV-2 is more stable when adsorbed on plastic surfaces urged us to examine whether the virus can attach to MP, which may facilitate infection upon inhalation or ingestion. Here, we describe that MP can bind SARS-CoV-2 pseudovirus on their surface and enhance infection of human cells in vitro. This enhanced in vitro infectivity was confirmed with authentic SARS-CoV-2, in parallel with increased expression of inflammation-related caspase-3, IL-8 and TNF-alpha genes. These results suggest that the presence of MP in the environment or in our respiratory or gastrointestinal tracts has the potential to interact with SARS-CoV-2, and potentially increase viral infectivity and spreading.

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