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Polar flagella rotation in Vibrio parahaemolyticus confers resistance to bacteriophage infection

文献类型： 外文期刊

作者： Zhang, Hui 1 ; Li, Lu 2 ; Zhao, Zhe 4 ; Peng, Daxin 5 ; Zhou, Xiaohui 2 ;

作者机构： 1.Jiangsu Acad Agr Sci, State Key Lab Cultivat Base MOST, Jiangsu Key Lab Food Qual & Safety, Nanjing 210014, Jiangsu, Peoples R China

2.Univ Connecticut, Dept Pathobiol & Vet Sci, 61 N Eagleville Rd, Storrs, CT 06269 USA

3.Univ Connecticut, Ctr Excellence Vaccine Res, 61 N Eagleville Rd, Storrs, CT 06269 USA

4.Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, Guangdong Prov Key Lab Appl Marine Biol, South China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China

5.Yangzhou Univ, Coll Vet Med, Yangzhou 225009, Jiangsu, Peoples R China

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）

ISSN： 2045-2322

年卷期： 2016 年 6 卷

页码：

收录情况： SCI

摘要： Bacteriophage has been recognized as a novel approach to treat bacterial infectious diseases. However, phage resistance may reduce the efficacy of phage therapy. Here, we described a mechanism of bacterial resistance to phage infections. In Gram-negative enteric pathogen Vibrio parahaemolyticus, we found that polar flagella can reduce the phage infectivity. Deletion of polar flagella, but not the lateral flagella, can dramatically promote the adsorption of phage to the bacteria and enhances the phage infectivity to V. parahaemolyticus, indicating that polar flagella play an inhibitory role in the phage infection. Notably, it is the rotation, not the physical presence, of polar flagella that inhibits the phage infection of V. parahaemolyticus. Strikingly, phage dramatically reduces the virulence of V. parahaemolyticus only when polar flagella were absent both in vitro and in vivo. These results indicated that polar flagella rotation is a previously unidentified mechanism that confers bacteriophage resistance.

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