您好，欢迎访问浙江省农业科学院 机构知识库！
浙江省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Biomimetic Microgrooved Methacrylated Silk Fibroin Cartilage Scaffold for Tracheal Injury Repair

文献类型： 外文期刊

作者： Wang, Bin 1 ; Wang, Lin 3 ; Yuan, Tao 4 ; Zhang, Yuming 1 ; Yang, Qian 1 ; Ou, Haibo 1 ; Zhang, Bingbing 1 ; Yang, Lei 2 ; Li, Shisheng 1 ;

作者机构： 1.Cent South Univ, Xiangya Hosp 2, Dept Otorhinolaryngol Head & Neck Surg, Changsha 410011, Peoples R China

2.Zhejiang Acad Agr Sci, Inst Sericulture & Tea, Hangzhou 310021, Peoples R China

3.Binzhou Peoples Hosp, Dept Otorhinolaryngol Head & Neck Surg, Binzhou 256610, Peoples R China

4.Cent South Univ, Xiangya Hosp 2, Dept Spine Surg, Changsha 410011, Peoples R China

关键词： microgroove; silk fibroin; stem cell; tracheal injuries

期刊名称：ADVANCED FUNCTIONAL MATERIALS （ 影响因子：19.0； 五年影响因子：19.4 ）

ISSN： 1616-301X

年卷期： 2025 年

页码：

收录情况： SCI

摘要： Bioengineered tracheas have shown considerable potential in tracheal injury repair; however, their practical value is limited by challenges in tracheal cartilage regeneration, and postoperative tracheal stenosis remains a common issue. Here, inspired by the 3-layer structure of the trachea and the multi-segmental characteristics of its cartilage, a multilayered bioengineered tracheal scaffold (named Sd@d-ECM/BMSCs/SilMA) with a microgroove structure is designed in this study to repair tracheal defects. In this design, the microgrooved surface of the methacrylated silk fibroin (SilMA) hydrogel provides spatial guidance for the directional growth of bone marrow mesenchymal stem cells (BMSCs) and enhances their adhesion and proliferation. The extracellular matrix of the decellularized cartilage scaffold offers the necessary microenvironment and mechanical support for BMSCs to differentiate into cartilage. Under the influence of the dual-layer structure (inner and outer), the middle-layer BMSCs can undergo stable chondrogenic differentiation without any inducing agents. Sd@d-ECM/BMSCs/SilMA effectively promotes tracheal cartilage formation in a rabbit defect model, reduces the incidence of tracheal stenosis, and substantially improves respiratory function. Sd@d-ECM/BMSCs/SilMA not only confirms the successful construction of microgroove structures on the surface of the SilMA hydrogel and the effective loading of BMSCs but also demonstrates significant experimental value in tracheal cartilage repair and regenerative medicine.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：浙江省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台