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Expression Levels of Myostatin and Matrix Metalloproteinase 14 mRNAs in Uterine Leiomyoma are Correlated With Dysmenorrhea

文献类型： 外文期刊

作者： Tsigkou, Anastasia 1 ; Reis, Fernando M. 2 ; Ciarmela, Pasquapina 3 ; Lee, Meng H. 1 ; Jiang, Bingjie 5 ; Tosti, Cl 1 ;

作者机构： 1.Xian Jiaotong Liverpool Univ, Dept Biol Sci, Suzhou, Peoples R China

2.Univ Fed Minas Gerais, Div Human Reprod, Belo Horizonte, MG, Brazil

3.Polytech Univ Marche, Dept Expt & Clin Med, Ancona, Italy

4.Polytech Univ Marche, Dept Informat Engn, Ancona, Italy

5.Guangzhou Univ, Guangzhou, Guangdong, Peoples R China

6.Univ Siena, Dept Mol & Dev Med Obstet & Gynecol, I-53100 Siena, Italy

7.Soochow Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Suzhou, Peoples R China

8.Jiangsu Acad Agr Sci, Inst Anim Sci, Lab Anim Breeding & Reprod, Nanjing, Jiangsu, Peoples R China

关键词： leiomyoma;matrix metalloproteinase;dysmenorrhea;activin-A;myostatin;MMP14;abnormal uterine bleeding

期刊名称：REPRODUCTIVE SCIENCES （ 影响因子：3.06； 五年影响因子：3.109 ）

ISSN： 1933-7191

年卷期： 2015 年 22 卷 12 期

页码：

收录情况： SCI

摘要： Uterine leiomyoma is the most common benign neoplasm of female reproductive system, found in about 50% of women in reproductive age. The mechanisms of leiomyoma growth include cell proliferation, which is modulated by growth factors, and deposition of extracellular matrix (ECM). Activin A and myostatin are growth factors that play a role in proliferation of leiomyoma cells. Matrix metalloproteinases (MMPs) are known for their ability to remodel the ECM in different biological systems. The aim of this study was to evaluate the expression levels of activin A-subunit, myostatin, and MMP14 messenger RNAs (mRNAs) in uterine leiomyomas and the possible correlation of these factors with clinical features of the disease. Matrix metalloproteinase 14 was highly expressed in uterine leiomyoma and correlated with myostatin and activin A mRNA expression. Moreover, MMP14 and myostatin mRNA expression correlated significantly and directly with the intensity of dysmenorrhea. Overall, the present findings showed that MMP14 mRNA is highly expressed in uterine leiomyoma, where it correlates with the molecular expression of growth factors and is further increased in cases of intense dysmenorrhea.

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[1]Disruption of the Myostatin Gene in Porcine Primary Fibroblasts and Embryos Using Zinc-Finger Nucleases. Huang, Xian-Ju,Zhang, Hong-Xiao,Xiong, Kai,Qin, Ling,Liu, Honglin,Wang, Huili. 2014

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