您好，欢迎访问湖北省农业科学院 机构知识库！
湖北省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

The Eukaryote-Like Serine/Threonine Kinase STK Regulates the Growth and Metabolism of Zoonotic Streptococcus suis

文献类型： 外文期刊

作者： Zhang, Chunyan 1 ; Sun, Wen 1 ; Tan, Meifang 2 ; Dong, Mengmeng 1 ; Liu, Wanquan 1 ; Gao, Ting 3 ; Li, Lu 1 ; Xu, Zhuofei 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan, Peoples R China

2.Jiangxi Acad Agr Sci, Inst Anim Husb & Vet Med, Vet Med Lab, Nanchang, Jiangxi, Peoples R China

3.Hubei Acad Agr Sci, Inst Anim Husb & Vet Sci, Vet Med Lab, Wuhan, Peoples R China

4.Cooperat Innovat Ctr Sustainable Pig Prod, Wuhan, Peoples R China

关键词： Streptococcus suis;eukaryote-like;serine/threonine kinase;phosphorylation;RNA-Seq;phosphoproteome;growth;virulence;metabolism

期刊名称：FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY （ 影响因子：5.293； 五年影响因子：5.882 ）

ISSN： 2235-2988

年卷期： 2017 年 7 卷

页码：

收录情况： SCI

摘要： Like eukaryotes, bacteria express one or more serine/threonine kinases (STKs) that initiate diverse signaling networks. The STK from Streptococcus suis is encoded by a single-copy stk gene, which is crucial in stress response and virulence. To further understand the regulatory mechanism of STK in S. suis, a stk deletion strain (1 stk) and its complementary strain (C Delta stk) were constructed to systematically decode STK characteristics by applying whole transcriptome RNA sequencing (RNA-Seq) and phosphoproteomic analysis. Numerous genes were differentially expressed in Delta stk compared with the wild-type parental strain SC-19, including 320 up-regulated and 219 down-regulated genes. Particularly, 32 virulence-associated genes (VAGs) were significantly down-regulated in Delta stk. Seven metabolic pathways relevant to bacterial centralmetabolismand translation are significantly repressed in Delta stk. Phosphoproteomic analysis further identified 12 phosphoproteins that exhibit differential phosphorylation in Delta stk. These proteins are associated with cell growth and division, glycolysis, and translation. Consistently, phenotypic assays confirmed that the Delta stk strain displayed deficient growth and attenuated pathogenicity. Thus, STK is a central regulator that plays an important role in cell growth and division, as well as S. suis metabolism.

  • 相关文献

[1]The 1910HK/RR two-component system is essential for the virulence of Streptococcus suis serotype 2. Yuan, Fangyan,Tan, Chen,Chen, Huanchun,Bei, Weicheng,Yuan, Fangyan,Liu, Zewen,Yang, Keli,Zhou, Danna,Liu, Wei,Duan, Zhengying,Guo, Rui,Tian, Yongxiang,Tan, Chen,Chen, Huanchun,Bei, Weicheng.

[2]Transcriptome Analyses Shed New Insights into Primary Metabolism and Regulation of Blumeria graminis f. sp tritici during Conidiation. Zeng, Fan-Song,Yang, Li-Jun,Yu, Da-Zhao,Zeng, Fan-Song,Xue, Min-Feng,Zhang, Xue-Jiang,Gong, Shuang-Jun,Yang, Li-Jun,Shi, Wen-Qi,Yu, Da-Zhao,Zeng, Fan-Song,Xue, Min-Feng,Zhang, Xue-Jiang,Gong, Shuang-Jun,Yang, Li-Jun,Shi, Wen-Qi,Yu, Da-Zhao,Menardo, Fabrizio. 2017

[3]GidA, a tRNA Modification Enzyme, Contributes to the Growth, and Virulence of Streptococcus suis Serotype 2. Gao, Ting,Tan, Meifang,Liu, Wanquan,Zhang, Chunyan,Zheng, Linlin,Zhu, Jiawen,Li, Lu,Zhou, Rui,Gao, Ting,Zhang, Tengfei,Gao, Ting,Li, Lu,Zhou, Rui. 2016

[4](p)ppGpp synthetases regulate the pathogenesis of zoonotic Streptococcus suis. Zhu, Jiawen,Zhang, Tengfei,Su, Zhipeng,Li, Lu,Wang, Dong,Xiao, Ran,Teng, Muye,Tan, Meifang,Zhou, Rui,Zhang, Tengfei,Li, Lu,Zhou, Rui.

[5]Genome-wide identification of allele-specific expression in response to Streptococcus suis 2 infection in two differentially susceptible pig breeds. Wu, Huayu,Gaur, Uma,Peng, Xianwen,Li, Lianghua,Sun, Hua,Song, Zhongxu,Dong, Binke,Li, Mingbo,Mei, Shuqi,Liu, Guisheng,Wu, Huayu,Gaur, Uma,Peng, Xianwen,Li, Lianghua,Sun, Hua,Dong, Binke,Mei, Shuqi,Liu, Guisheng,Mekchay, Supamit,Wimmers, Klaus,Ponsuksili, Siriluck,Li, Kui.

[6]Gene Expressions in Major Organs between Enshi Black and Landrace Pigs after Streptococcus suis Infection. Gaur, Uma,Wu, Hua-Yu,Feng, Zheng,Yang, Xue-Hai,Guo, Rui,Wu, Jun-Jing,Mei, Shu-Qi,Liu, Gui-Sheng,Gaur, Uma,Wu, Hua-Yu,Feng, Zheng,Yang, Xue-Hai,Guo, Rui,Wu, Jun-Jing,Mei, Shu-Qi,Liu, Gui-Sheng,Li, Kui,Jin, Mei-Lin.

[7]The involvement of MsmK in pathogenesis of the Streptococcus suis serotype 2. Tan, Mei-Fang,Liu, Wan-Quan,Zhang, Chun-Yan,Zheng, Lin-Lin,Qiu, De-Xin,Li, Lu,Zhou, Rui,Tan, Mei-Fang,Gao, Ting,Li, Lu,Zhou, Rui. 2017

[8]高低产蛋鸡产蛋后期卵巢组织差异表达基因筛选及其功能分析. 陈林,王家乡,吴艳,皮劲松,蒲跃进. 2024

[9]利用转录组技术鉴定影响硒都黑猪肌内脂肪含量性状关键基因及标记的研究. 吴俊静,田海斌,刘晓哲,乔木,周佳伟,孙华,彭先文,梅书棋. 2023

[10]Effects of cyclic AMP on development and secondary metabolites of Monascus ruber M-7. Chen, F.,Chen, F.,Lai, Y.,Wang, L.,Qing, L.,Chen, F.. 2011

[11]Gene expression profiling reveals candidate genes related to residual feed intake in duodenum of laying ducks. Zeng, T.,Huang, L.,Ren, J.,Chen, L.,Tian, Y.,Lu, L.,Huang, L.,Huang, Y.,Zhang, H.,Du, J.. 2017

[12]Effect of the glycosyltransferases on the capsular polysaccharide synthesis of Streptococcus suis serotype 2. Zhang, Yanyan,Ding, Dandan,Yang, Xiaopei,Zong, Bingbing,Wang, Xiangru,Chen, Huanchun,Bei, Weicheng,Tan, Chen,Liu, Manli,Zhang, Yanyan,Ding, Dandan,Yang, Xiaopei,Zong, Bingbing,Wang, Xiangru,Chen, Huanchun,Bei, Weicheng,Tan, Chen,Zhang, Yanyan,Ding, Dandan,Yang, Xiaopei,Zong, Bingbing,Wang, Xiangru,Chen, Huanchun,Bei, Weicheng,Tan, Chen.

[13]The two-component system NisK/NisR contributes to the virulence of Streptococcus suis serotype 2. Xu, Juan,Fu, Shulin,Xu, Qiaoxia,Bei, Weicheng,Chen, Huanchun,Tan, Chen,Xu, Juan,Fu, Shulin,Xu, Qiaoxia,Bei, Weicheng,Chen, Huanchun,Tan, Chen,Liu, Manli.

[14]Deletion of the znuA virulence factor attenuates Actinobacillus pleuropneumoniae and confers protection against homologous or heterologous strain challenge. Yuan, Fangyan,Liu, Zewen,Zhou, Danna,Tian, Yongxiang,You, Wujin,Tan, Yongqiang,Zheng, Chengkun,BinWang,Bei, Weicheng,Liao, Yonghong.

[15]Actinobacillus pleuropneumoniae two-component system QseB/QseC regulates the transcription of PilM, an important determinant of bacterial adherence and virulence. Liu, Jinlin,Hu, Linlin,Xu, Zhuofei,Tan, Chen,Fu, Shulin,Cheng, Hui,Chen, Huanchun,Bei, Weicheng,Liu, Jinlin,Yuan, Fangyan.

[16]Virulence and Diversity of Blumeria graminis f. sp. tritici Populations in China. Zeng Fan-song,Yang Li-jun,Gong Shuang-jun,Zhang Xue-jiang,Wang Hua,Xiang Li-bo,Xue Min-Feng,Yu Da-zhao,Zeng Fan-song,Yu Da-zhao. 2014

[17]Breed-specific transcriptome response of spleen from six to eight week old piglet after infection with Streptococcus suis type 2. Gaur, U.,Luo, Q. P.,Yuan, F. Y.,Wu, H. Y.,Qiao, M.,Mei, S. Q.,Liu, G. S.,Gaur, U.,Luo, Q. P.,Yuan, F. Y.,Wu, H. Y.,Qiao, M.,Mei, S. Q.,Liu, G. S.,Xiong, Y. Y.,Wimmers, K.,Li, K..

[18]An RNA-Seq screen of the dithiothreitol-induced apoptosis response in chicken cardiomyocytes. Wan, Chunyun,Wan, Chunyun,Xiang, Jinmei,Yang, Shijin,Li, Youwen,Guo, Dingzong,Xiang, Jinmei,Guo, Rui. 2017

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：湖北省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台