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Marek's disease virus-encoded microRNAs: genomics, expression and function

文献类型： 外文期刊

作者： Luo Jun 1 ; Teng Man 1 ; Fan JianMing 1 ; Wang FangYu 1 ; Zhou Ling 1 ; Deng RuiGuang 1 ; Zhang GaiPing 1 ;

作者机构： 1.Henan Acad Agr Sci, Henan Prov Key Lab Anim Immunol, Minist Agr, Key Lab Anim Immunol, Zhengzhou 450002, Peoples R China

2.Zhengzhou Univ, Coll Publ Hlth, Toxicol Lab, Zhengzhou 450001, Peoples R China

关键词： MDV;miRNA;herpesvirus;cancer;tumorigenesis

期刊名称：SCIENCE CHINA-LIFE SCIENCES （ 影响因子：6.038； 五年影响因子：4.754 ）

ISSN： 1674-7305

年卷期： 2010 年 53 卷 10 期

页码：

收录情况： SCI

摘要： MicroRNAs (miRNAs) are the recently discovered small non-coding RNA molecules that have post-transcriptional regulatory functions in many important biological processes. A large number of miRNAs have been found to be encoded by viral genomes, especially in herpesviruses. Previous research regarding miRNAs encoded by herpesviruses, including Marek's disease virus (MDV), has demonstrated their involvement in lytic replication, latent infection, T-lymphocyte transformation and tumorigenesis. MDV is an oncogenic alphaherpesvirus, with the ability to induce tumors in natural hosts; however, formation of these tumors can be prevented by immunization with attenuated or nonpathogenic forms of the virus. Marek's disease is considered to be a good biomedical model for investigating the biology, genetics, and immunology of tumorigenesis. In this paper, we review the discovery and identification of MDV-encoded miRNAs, along with their genomics, expression profiles, and currently known functions. We also discuss the prospects and techniques possibly applicable to the further investigation of the biological roles of MDV-encoded miRNAs.

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