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Differential Replication and Cytokine Response between Vaccine and Very Virulent Marek's Disease Viruses in Spleens and Bursas during Latency and Reactivation

文献类型： 外文期刊

作者： Jiang, Bo 1 ; Wang, Jing 1 ; Cao, Mengyao 1 ; Jin, Huan 1 ; Liu, Wenxiao 1 ; Cheng, Jing 1 ; Zhou, Linyi 1 ; Xu, Jian 1 ; Li, Yongqing 1 ;

作者机构： 1.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing 100097, Peoples R China

2.China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China

3.Beijing Univ Agr, Coll Anim Sci & Technol, Beijing 102206, Peoples R China

4.Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Lanzhou 730070, Peoples R China

关键词： Marek's disease virus; lymphoid organs; virus duplication; cytokines

期刊名称：VIRUSES-BASEL （ 影响因子：4.7； 五年影响因子：4.8 ）

ISSN：

年卷期： 2023 年 15 卷 1 期

页码：

收录情况： SCI

摘要： Marek's disease virus (MDV) infection results in Marek's disease (MD) in chickens, a lymphoproliferative and oncogenic deadly disease, leading to severe economic losses. The spleen and bursa are the most important lymphoid and major target organs for MDV replication. The immune response elicited by MDV replication in the spleen and bursa is critical for the formation of latent MDV infection and reactivation. However, the mechanism of the host immune response induced by MDV in these key lymphoid organs during the latent and reactivation infection phases is not well understood. In the study, we focused on the replication dynamics of a vaccine MDV strain MDV/CVI988 and a very virulent MDV strain MDV/RB1B in the spleen and bursa in the latent and reactivation infection phases (7-28 days post-inoculation [dpi]), as well as the expression of some previously characterized immune-related molecules. The results showed that the replication ability of MDV/RB1B was significantly stronger than that of MDV/CVI988 within 28 days post-infection, and the replication levels of both MDV strains in the spleen were significantly higher than those in the bursa. During the latent and reactivation phase of MDV infection (7-28 dpi), the transcriptional upregulation of chicken IL-1 beta, IL6, IL-8L1 IFN-gamma and PML in the spleen and bursa induced by MDV/RB1B infection was overall stronger than that of MDV/CVI988. However, compared to MDV/RB1Binfection, MDV/CVI988 infection resulted in a more effective transcriptional activation of CCL4 in the latent infection phase (7-14 dpi), which may be a characteristic distinguishing MDV vaccine strain from the very virulent strain.

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