A novel hedgehog inhibitor iG2 suppresses tumorigenesis by impairing self-renewal in human bladder cancer
文献类型： 外文期刊
作者： Zhu, Lihong 1 ; Ni, Chen 2 ; Dong, Baijun 3 ; Zhang, Yong 4 ; Shi, Yuefeng 1 ; Niu, Haitao 4 ; Li, Chong 5 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, Hangzhou 310021, Zhejiang, Peoples R China
2.Zhengzhou Univ, Affiliated Hosp 1, Med Res Ctr, Zhengzhou 450052, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Urol, Shanghai 200127, Peoples R China
4.Qingdao Univ, Affiliated Hosp, Dept Urol, Qingdao 266003, Peoples R China
5.Chinese Acad Sci, Inst Biophys, CAS Key Lab Infect & Immun, Lab Anim Ctr, Beijing 100101, Peoples R China
关键词： Bladder cancer;Gli2;hedgehog;iG2
期刊名称：CANCER MEDICINE （ 影响因子：4.452； 五年影响因子：4.609 ）
ISSN： 2045-7634
年卷期： 2016 年 5 卷 9 期
页码：
收录情况： SCI
摘要： Tumor recurrence is still a major challenge for clinical treatment of bladder cancer. Cumulative evidences indicate cancer stem cells (CSCs) contribute to drug resistance and leave a putative source for disease relapse. Identifying novel agents targeting CSCs may represent a new paradigm in the therapy of bladder cancer. Here, we separated a novel hedgehog (Hh) inhibitor, iG2, from streptomyces roseofulvus, which dramatically blocked the activation of Gli2 in bladder cancer cells. The iG2 strongly repressed the growth of cancer cells rather than the peri-tumor stroma cells. Attenuated proliferation and enhanced apoptosis of tumor cells were observed upon iG2 stimulation. Furthermore, iG2 reduced the self-renewal ability of bladder CSCs as well as the tumor formation. Collectively, iG2 is potentially used as a novel therapeutic agent for bladder cancer by targeting self-renewal through inhibiting Hh pathway.
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