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Mycoreovirus 1 S4-coded protein is dispensable for viral replication but necessary for efficient vertical transmission and normal symptom induction

文献类型： 外文期刊

作者： Eusebio-Cope, Ana 1 ; Sun, Liying 2 ; Hillman, Bradley I. 3 ; Suzuki, Nobuhiro 1 ;

作者机构： 1.Okayama Univ, Res Inst Bioresources, Agrivirol Lab, Okayama 7100046, Japan

2.Zhejiang Acad Agr Sci, Inst Virol & Biotechnol, Zhejiang Prov Key Lab Plant Virol, Hangzhou 310021, Zhejiang, Peoples R China

3.Rutgers State Univ, Dept Plant Biol & Pathol, New Brunswick, NJ 08901 USA

关键词： Mycovirus;Reovirus;Rearrangement;Virus transmission;Hypovirulence;dsRNA;Chestnut blight;Virocontrol;Cryphonectria parasitica;Symptom expression

期刊名称：VIROLOGY （ 影响因子：3.616； 五年影响因子：3.967 ）

ISSN： 0042-6822

年卷期： 2010 年 397 卷 2 期

页码：

收录情况： SCI

摘要： Rearrangements of two segments, S6 and S10, of Mycoreovirus 1 (MyRV1), a member of the family Reoviridae, were previously shown to be induced at a high rate by the multifunctional protein p29 encoded by a distinct ssRNA virus, the prototype hypovirus CHV1-EP713 (Sun and Suzuki, RNA 14, 2557-2571, 2008). Here we report the occurrence of rearrangements of MyRV1 S4. albeit at a very low frequency, in the absence of CHV1 p29, resulting in internal 80-90% deletions of the open reading frame (ORF) in S4. Comparative analyses of fungal strains infected by wild-type MyRV1 and its variants carrying rearrangements of S4, S4 Plus S10 and S10 indicated that S4-encoded VP4, like VP10, is non-essential for virus replication but required for efficient vertical transmission and symptom expression caused by MyRV1. This is the first example of a reovirus variant that carries deletions of over 75% of the ORFs in two genome segments and is still replication-competent. (C) 2009 Elsevier Inc. All rights reserved.

  • 相关文献

[1]Mycoreovirus genome alterations: similarities to and differences from rearrangements reported for other reoviruses. Tanaka, Toru,Eusebio-Cope, Ana,Suzuki, Nobuhiro,Sun, Liying. 2012

[2]The Complete Genome Sequence of Two Isolates of Southern rice black-streaked dwarf virus, a New Member of the Genus Fijivirus. Wang, Qiang,Zhou, Guo-Hui,Yang, Jian,Zhang, Heng-Mu,Chen, Jian-Ping,Adams, Michael J..

[3]Whole blood transcriptome comparison of pigs with extreme production of in vivo dsRNA-induced serum IFN-a. Liu, Xiangdong,Huang, Jing,Yang, Songbai,Zhao, Yunxia,Xiang, Anjing,Cao, Jianhua,Fan, Bin,Zhao, Shuhong,Zhu, Mengjin,Liu, Xiangdong,Huang, Jing,Yang, Songbai,Zhao, Yunxia,Xiang, Anjing,Cao, Jianhua,Fan, Bin,Zhao, Shuhong,Zhu, Mengjin,Liu, Xiangdong,Zhao, Junlong,Wu, Zhenfang,Huang, Jing.

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