Overexpression of the PDCD2-like gene results in Inhibited TNF-alpha production in activated Daudi cells
文献类型： 外文期刊
作者： Chen, Q. 2 ; Yan, C. -Q. 1 ; Liu, F. -J. 2 ; Tong, J. 2 ; Miao, S. -L. 2 ; Chen, J. -P. 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Virol & Biotechnol, Hangzhou 310021, Peoples R China
2.Soochow Univ, Sch Radiol & Publ Hlth, Suzhou 215123, Peoples R China
关键词： PDCD2-like;TNF-alpha;PDCD2;anti-inflammation
期刊名称：HUMAN IMMUNOLOGY （ 影响因子：2.85； 五年影响因子：2.591 ）
ISSN： 0198-8859
年卷期： 2008 年 69 卷 4-5 期
页码：
收录情况： SCI
摘要： Both PDCD2 and PDCD2-like proteins have PDCD2_C terminal domains, but their functions are stilt unclear. After analysis of their expression in Gene Expression Omnibus, we hypothesized that they played a rote in inflammation. In Daudi cells exposed to Lipopolysaccharides, PDCD2-like RNA was upregulated, whereas PDCD2 was downregulated. Overexpression of PDCD2-like gene effectively attenuated tumor necrosis factor (TNF)-alpha release but elevated interteukin (IL)-6 and PDCD2 expression induced by lipopolysaccharide (LPS). It is possible that both proteins have anti-inflammatory effects Like IL-6. The results have implications for understanding the function of PDCD2/PDCD2-like proteins and may help in the development of novel anti-inflammatory drugs. (C) 2008 American Society for Histocompatibitity and Immunogenetics. Published by Elsevier Inc. All rights reserved.
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