Bidirectional Estrogen-Like Effects of Genistein on Murine Experimental Autoimmune Ovarian Disease
文献类型： 外文期刊
作者： Ding, Qiao 1 ; Wang, Yuxiao 1 ; Li, Na 1 ; Zhu, Kexue 2 ; Hu, Jielun 1 ; Wang, Sunan 3 ; Zhu, Fan 4 ; Nie, Shaoping 1 ;
作者机构： 1.Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China
2.Chinese Acad Trop Agr Sci, Spice & Beverage Res Inst, Wanning 571533, Peoples R China
3.Niagara Coll, Canadian Food & Wine Inst, 135 Taylor Rd, Niagara On The Lake, ON L0S 1J0, Canada
4.Univ Auckland, Sch Chem Sci, Private Bag 92019, Auckland 92019, New Zealand
关键词： autoimmune ovarian disease;genistein;zona pellucida;oophoritis;estradiol
期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）
ISSN： 1422-0067
年卷期： 2016 年 17 卷 11 期
页码：
收录情况： SCI
摘要： This study was to investigate the bidirectional estrogen-like effects of genistein on murine experimental autoimmune ovarian disease (AOD). Female BALB/c mice were induced by immunization with a peptide from murine zona pellucida. The changes of estrous cycle, ovarian histomorphology were measured, and the levels of serum sex hormone were analyzed using radioimmunoassay. Proliferative responses of the ovary were also determined by immunohistochemistry. Administration of 25 or 45 mg/kg body weight genistein enhanced ovary development with changes in serum sex hormone levels and proliferative responses. Meanwhile, the proportions of growing and mature follicles increased and the incidence of autoimmune oophoritis decreased, which exhibited normal ovarian morphology in administration of 25 or 45 mg/kg body weight genistein, while a lower dose (5 mg/kg body weight genistein) produced the opposite effect. These findings suggest that genistein exerts bidirectional estrogen-like effects on murine experimental AOD, while a high dose (45 mg/kg body weight) of genistein may suppress AOD.
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