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Manufacturing Techniques and Surface Engineering of Polymer Based Nanoparticles for Targeted Drug Delivery to Cancer

文献类型： 外文期刊

作者： Wang, Yichao 1 ; Li, Puwang 2 ; Thao Truong-Dinh Tran 2 ; Zhang, Juan 2 ; Kong, Lingxue 2 ;

作者机构： 1.RMIT Univ, Sch Elect & Comp Engn, Melbourne, Vic 3000, Australia

2.Deakin Univ, Inst Frontier Mat, Locked Bag 20000, Geelong, Vic 3220, Australia

3.Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China

4.Vietnam Natl Univ, Int Univ, Dept Biomed Engn, Pharmaceut Engn Lab, Ho Chi Minh City 70000, Vietnam

关键词： nanoparticles;PLGA;chitosan;nano;microencapsulation;drug delivery;top-down fabrication techniques

期刊名称：NANOMATERIALS （ 影响因子：5.076； 五年影响因子：5.346 ）

ISSN： 2079-4991

年卷期： 2016 年 6 卷 2 期

页码：

收录情况： SCI

摘要： The evolution of polymer based nanoparticles as a drug delivery carrier via pharmaceutical nano/microencapsulation has greatly promoted the development of nano- and micro-medicine in the past few decades. Poly(lactide-co-glycolide) (PLGA) and chitosan, which are biodegradable and biocompatible polymers, have been approved by both the Food & Drug Administration (FDA) and European Medicine Agency (EMA), making them ideal biomaterials that can be advanced from laboratory development to clinical oral and parental administrations. PLGA and chitosan encapsulated nanoparticles (NPs) have successfully been developed as new oral drug delivery systems with demonstrated high efficacy. This review aims to provide a comprehensive overview of the fabrication of PLGA and chitosan particulate systems using nano/microencapsulation methods, the current progress and the future outlooks of the nanoparticulate drug delivery systems. Especially, we focus on the formulations and nano/micro-encapsulation techniques using top-down techniques. It also addresses how the different phases including the organic and aqueous ones in the emulsion system interact with each other and subsequently influence the properties of the drug delivery system. Besides, surface modification strategies which can effectively engineer intrinsic physicochemical properties are summarised. Finally, future perspectives and potential directions of PLGA and chitosan nano/microencapsulated drug systems are outlined.

  • 相关文献

[1]Chitosan-Modified PLGA Nanoparticles with Versatile Surface for Improved Drug Delivery. Wang, Yichao,Li, Puwang,Kong, Lingxue,Li, Puwang. 2013

[2]Microencapsulation of coupled folate and chitosan nanoparticles for targeted delivery of combination drugs to colon. Li, Puwang,Yang, Ziming,Peng, Zheng,Li, Sidong,Kong, Lingxue,Wang, Qinghuang,Wang, Yichao,Kong, Lingxue,Wang, Qinghuang. 2015

[3]Formulation Optimization For High Drug Loading Colonic Drug Delivery Carrier. Wang, Yichao,Li, Puwang,Kong, Lingxue,Peng, Zheng,Luo, Yongyue. 2010

[4]Development of Ligand Incorporated Chitosan Nanoparticles for the Selective Delivery of 5-Fluorouracil to Colon. Li, Puwang,She, F. H.,Kong, L. X.,Li, Puwang,Li, Puwang,Peng, Zheng. 2011

[5]Formulation of vanillin cross-linked chitosan nanoparticles and its characterization. Wang, Guang,Li, Puwang,Peng, Zheng,Huang, Maofang,Kong, Lingxue. 2011

[6]Development of drug-loaded chitosan-vanillin nanoparticles and its cytotoxicity against HT-29 cells. Li, Pu-Wang,Wang, Guang,Yang, Zi-Ming,Peng, Zheng,Wang, Qing-Huang,Duan, Wei,Kong, Ling-Xue,Wang, Qing-Huang.

[7]Synthesis and characterization of chitosan quaternary ammonium salt and its application as drug carrier for ribavirin. Li, Si-Dong,Quan, Wei-Yan,Yang, Lei,Dong, Jing-Jing,Li, Pu-Wang,Yang, Zi-Ming,Peng, Zheng,Yang, Xi-Hong.

[8]Microencapsulation of lipase produced omega-3 concentrates resulted in complex coacervates with unexpectedly high oxidative stability. Xia, Qiuyu,Wang, Bo,Akanbi, Taiwo O.,Li, Rui,Yang, Wenrong,Barrow, Colin J.,Xia, Qiuyu,Li, Rui,Adhikari, Benu.

[9]Design of microencapsulated carbon nanotube-based microspheres and its application in colon targeted drug delivery. Zhou, Min,Peng, Zheng,Li, Puwang,Zhou, Min,Liao, Shuangquan,Li, Sidong.

[10]Nanogels fabricated by lysozyme and sodium carboxymethyl cellulose for 5-fluorouracil controlled release. Zhu, Kunkun,Ye, Ting,Liu, Jinjin,Xu, Shasha,Lei, Jieqiong,Deng, Hongbing,Li, Bin,Zhu, Kunkun,Ye, Ting,Liu, Jinjin,Xu, Shasha,Lei, Jieqiong,Deng, Hongbing,Li, Bin,Zhu, Kunkun,Peng, Zheng.

[11]Targeted delivery of 5-fluorouracil to HT-29 cells using high efficient folic acid-conjugated nanoparticles. Wang, Yichao,Li, Puwang,Chen, Lijue,Gao, Weimin,Kong, Ling Xue,Li, Puwang,Zeng, Fanbo.

[12]Preparation of a Xanthine Sensor Based on the Immobilization of Xanthine Oxidase on a Chitosan Modified Electrode by Cross-linking. Liu Yuge,Li Weiming,Wei Changbin,Lu Lingling. 2012

[13]Preparation of nanoparticles by crosslinking folate conjugated chitosan with vanillin and its characterization. Zhou, Min,Li, Puwang,Wang, Guang,Yang, Ziming,Peng, Zheng,Kong, Lingxue. 2012

[14]Soybean oil-chitosan emulsion affects internal quality and shelf-life of eggs stored at 25 and 4 degrees C. Wardy, Wisdom,Torrico, Damir D.,Zhang, Xiumei,Xu, Zhimin,Prinyawiwatkul, Witoon,Herrera Corredor, Jose A.,No, Hong Kyoon,Zhang, Xiumei. 2013

[15]Preparation and Characterization of Novel Chitosan-Based Microcapsule Containing Patchouli Oil. Yang, Ziming,Huang, Maofang,Peng, Zheng,Han, Guangtao,Li, Puwang,Yang, Ziming,Pang, Yuxin,Kong, Lingxue. 2013

[16]Preparation and Mechanical Properties of Prevulcanized Natural Rubber Latex/Chitosan/Poly (3-hydroxybutyrate) Blends. Lu, Guang,Yu, Heping,Wang, Yongzhou,Luo, Yongyue,Zeng, Zongqiang. 2015

[17]Preparation and Properties of Interpenetrating Polymer Network Films from Prevulcanized Natural Rubber Latex/Chitosan Blends. Lu, Guang,Yu, Heping,Zeng, Zongqiang,Luo, Yongyue. 2012

[18]Preparation and evaluation of chitosan/alginate porous microspheres/Bletilla striata polysaccharide composite hemostatic sponges. Wang, Chao,Luo, Wenfeng,Ao, Ningjian,Wang, Chao,Li, Puwang,Yang, Ziming,Liu, Yangyang,Li, Sidong,Hu, Zhang. 2017

[19]Effect of chitosan/nano-silica coating on the physicochemical characteristics of longan fruit under ambient temperature. Shi, Shengyou,Wang, Wei,Liu, Liqin,Wei, Yongzan,Li, Weicai,Wang, Wei,Wu, Shijia.

[20]Thermal degradation of hydroxypropyl trimethyl ammonium chloride chitosan-Cd complexes. Li, Si-Dong,Yang, Xi-Hong,Yang, Lei,Li, Si-Dong,Li, Pu-Wang,Yang, Zi-Ming,Dong, Jing-Jing.

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