文献类型： 外文期刊
作者： Yang, Mo 1 ; Hu, Dong 2 ; Cui, Zhengying 1 ; Li, Hongxuan 1 ; Man, Chaoxin 1 ; Jiang, Yujun 1 ;
作者机构： 1.Northeast Agr Univ, Minist Educ, Dept Food Sci, Key Lab Dairy Sci, Harbin 150030, Peoples R China
2.Hebei Acad Agr & Forestry Sci, Inst Genet & Physiol, Shijiazhuang 050051, Hebei, Peoples R China
关键词： Inonotus obliquus polysaccharide; HepG2 cells; high-fat diet; lipid lowering
期刊名称：FOODS （ 影响因子：5.561； 五年影响因子：5.94 ）
ISSN：
年卷期： 2021 年 10 卷 12 期
页码：
收录情况： SCI
摘要： Excessive lipid intake will cause hyperlipidemia, fatty liver metabolism disease, and endanger people's health. Edible fungus polysaccharide is a natural active substance for lipid lowering. In this study, the HepG2 cell model induced by oleic acid and mice model induced by a high-fat diet was established. The lipid-lowering effects of Inonotus obliquus polysaccharide (IOP) was investigated in vivo and in vitro. Glucose (251.33 mg/g), rhamnose (11.53 mg/g), ribose (5.10 mg/g), glucuronic acid (6.30 mg/g), and galacturonic acid (2.95 mg/g) are present in IOP, at a ratio of 85.2:3.91:1.73:2.14:1. The molecular weight of IOP is 42.28 kDa. Treatment with 60 mg/L of IOP showed a significant lipid-lowering effect in HepG2 cells compared with the oleic acid-treated group. In the oil red O-stained images, the red fat droplets in the IOP-treated groups were significantly reduced. TC and TG levels of IOP-treated groups decreased. IOP can alleviate the lipid deposition in the mice liver due to high-fat diet, and significantly reduce their serum TC, TG, and LDL-C contents. IOP could activate AMPK but decrease the SREBP-1C, FAS, and ACC protein expression related to adipose synthesis in mice. IOP has a certain potential for lipid-lowering effects both in vivo and in vitro.
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