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Isolation and Characterization of an alpha-Glucosidase Inhibitor from Musa spp. (Baxijiao) Flowers

文献类型： 外文期刊

作者： Sheng, Zhanwu 1 ; Dai, Haofu 3 ; Pan, Siyi 1 ; Wang, Hui 4 ; Hu, Yingying 4 ; Ma, Weihong 2 ;

作者机构： 1.Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Peoples R China

2.Chinese Acad Trop Agr Sci, Haikou Expt Stn, Hainan Key Lab Banana Genet Improvement, Haikou 570101, Peoples R China

3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

4.Hainan Univ, Coll Food Sci & Technol, Haikou 570228, Peoples R China

关键词： alpha-glucosidase;inhibitor;hyperglycemia;flowers of Musa spp. (Baxijiao)

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN： 1420-3049

年卷期： 2014 年 19 卷 7 期

页码：

收录情况： SCI

摘要： The use of alpha-glucosidase inhibitors is considered to be an effective strategy in the treatment of diabetes. Using a bioassay-guided fractionation technique, five Bacillus stearothermophilus alpha-glucosidase inhibitors were isolated from the flowers of Musa spp. (Baxijiao). Using NMR spectroscopy analysis they were identified as vanillic acid (1), ferulic acid (2), beta-sitosterol (3), daucosterol (4) and 9-(4'-hydroxyphenyl)-2-methoxyphenalen-1-one (5). The half maximal inhibitory concentration (IC50) values of compounds 1-5 were 2004.58, 1258.35, 283.67, 247.35 and 3.86 mg/L, respectively. Compared to a known alpha-glucosidase inhibitor (acarbose, IC50 = 999.31 mg/L), compounds 3, 4 and 5 showed a strong alpha-glucosidase inhibitory effect. A Lineweaver-Burk plot indicated that compound 5 is a mixed-competitive inhibitor, while compounds 3 and 4 are competitive inhibitors. The inhibition constants (K-i) of compounds 3, 4 and 5 were 20.09, 2.34 and 4.40 mg/L, respectively. Taken together, these data show that the compounds 3, 4 and 5 are potent alpha-glucosidase inhibitors.

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[1]Ability of resveratrol to inhibit advanced glycation end product formation and carbohydrate-hydrolyzing enzyme activity, and to conjugate methylglyoxal. Shen, Yixiao,Sheng, Zhanwu,Shen, Yixiao,Xu, Zhimin. 2017

[2]Phytosterols in banana (Musa spp.) flower inhibit alpha-glucosidase and alpha-amylase hydrolysations and glycation reaction. Sheng, Zhanwu,Pan, Siyi,Sheng, Zhanwu,Ai, Binling,Zheng, Lili,Zheng, Xiaoyan,Dai, Haofu,Prinyawiwatkul, Witoon,Xu, Zhimin.

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