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Synthesis and insect antifeedant activity of stilbene derivatives against Brontispa longissima Larvae

文献类型： 外文期刊

作者： Liu, Ying-Qian 1 ; Li, Xiao-Jing 1 ; Zhao, Chun-Yan 1 ; Lu, Yan 1 ; Li, Wen-Qun 1 ; Liu, Zhen-Ling 4 ; Feng, Gang 2 ; Yan 1 ;

作者机构： 1.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China

2.Chinese Acad Trop Agr Sci, Environm & Plant Protect Inst, Danzhou 571737, Peoples R China

3.Lanzhou Jiaotong Univ, Environm & Municipal Engn Sch, Lanzhou 730000, Peoples R China

4.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

关键词： Stilbenes;insect antifeedants;Brontispa longissima;CoMFA;3D-QSAR study

期刊名称：MEDICINAL CHEMISTRY RESEARCH （ 影响因子：1.965； 五年影响因子：1.98 ）

ISSN： 1054-2523

年卷期： 2013 年 22 卷 5 期

页码：

收录情况： SCI

摘要： Continuing our search for natural product-based compounds for the control of B. longissima Larvae, 25 stilbene analogs were synthesized and evaluated for insect antifeedant activity against third-instar larvae of B. longissima for the first time. Among all the tested compounds, especially compounds 3a, 3c, and 6 showed pronounced antifeedant activities with AFC(50) values of 0.218, 0.327, and 0.226 mg/mL, respectively. The different antifeedant activity ranges of these compounds indicated that variation of chemical structures in the stilbene skeleton markedly affected the activity profiles of this compound class, and some important SAR information has been revealed from it. In addition, to understand the structural requirements for antifeedant activities of the 25 synthesized stilbene analogs, a comparative molecular field analysis (CoMFA) model, which yielded the leave-one-out (LOO) cross-validated correlation coefficient (q (2)) of 0.533 and a non-cross-validated correlation coefficient (r (2)) of 0.929, was constructed. Together, these preliminary results may be useful in guiding further modification of stilbenes in the development of potential new antifeedants.

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