4 beta-Isocyanopodophyllotoxins: valuable precursors for the synthesis of new podophyllotoxin analogues
文献类型： 外文期刊
作者： Liu, Ying-Qian 1 ; Li, Lin-Hai 1 ; Li, Wen-Qun 1 ; Feng, Gang 2 ; Yang, Liu 3 ;
作者机构： 1.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China
2.Chinese Acad Trop Agr Sci, Environm & Plant Protect Inst, Danzhou 571737, Peoples R China
3.Lanzhou Jiaotong Univ, Environm & Municipal Engn Sch, Lanzhou 730000, Peoples R China
关键词： 4 beta-isocyanopodophyllotoxins;anticancer drugs;multicomponent reactions;ultrasound
期刊名称：CHEMICAL PAPERS （ 影响因子：2.097； 五年影响因子：1.831 ）
ISSN： 0366-6352
年卷期： 2011 年 65 卷 5 期
页码：
收录情况： SCI
摘要： A new and efficient method for the synthesis of novel 4 beta-isocyanopodophyllotoxins as a valuable building block for the synthesis of versatile bioactive podophyllotoxin analogues under both classical and ultrasonic conditions was developed. In general, significant improvements in rates of reaction and yields of sonochemical reactions relative to the classical ones were observed.
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