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DNA damage protection and 5-lipoxygenase inhibiting activity of areca (Areca catechu L.) inflorescence extracts

文献类型： 外文期刊

作者： Chen, Weijun 1 ; Zhang, Chunmei 1 ; Huang, Yulin 1 ; Cheng, Fangfang 4 ; Zhao, Songlin 1 ; Shen, Yan 1 ; Liu, Jiangkan 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Coconut Res Inst, Wenchang 571339, Hainan, Peoples R China

2.Natl Technol & Engn Ctr Key Trop Prod, Danzhou 571737, Hainan, Peoples R China

3.Hunan Agr Univ, Coll Landscape & Hort, Changsha 410128, Hunan, Peoples R China

4.Guilin Univ Technol, Coll Chem & Bioengn, Guilin Guangxi 541004, Peoples R China

5.Xi An Jiao Tong Univ, Sch Life Sci & Technol, Xian 710049, Shanxi, Peoples R China

关键词： Areca inflorescence extracts;trolox;DNA damage;antioxidant

期刊名称：AFRICAN JOURNAL OF BIOTECHNOLOGY （ 影响因子：0.573； 五年影响因子：0.794 ）

ISSN： 1684-5315

年卷期： 2011 年 10 卷 55 期

页码：

收录情况： SCI

摘要： DNA damage caused by free radical is associated with mutation-based health impairment. The protective effect on DNA damage mediated by hydroxyl radical and peroxynitrite radical, and the inhibiting activity on 5-lipoxygenase of areca inflorescence extracts were studied in vitro. The results show that the boiling water extract significantly restrain the oxidative damage of pBR322 plasmid DNA induced by free radical, and synergize with trolox. Also, the inhibiting activity of boiling water extract on 5-lipoxygenase was higher than that of trolox. The antioxidant evaluation shows that the boiling water extract has the strongest inhibiting activity on beta-carotene autoxidation and the scavenging activity on ABTS radical cation. The total phenolics concentration for boiling water extract was 5.81 mg GAE/g.

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