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Mechanism of membrane damage to Shigella sonnei by linalool from plant essential oils: A driver of oxidative stress

文献类型： 外文期刊

作者： He, Rongrong 1 ; Wu, Hao 1 ; Liu, Jicai 1 ; Chen, Wenxue 1 ; Chen, Weijun 1 ; Chen, Haiming 1 ; Zhong, Qiuping 1 ; Zhang, Ming 1 ; Gu, Fenglin 2 ;

作者机构： 1.Hainan Univ, Coll Food Sci & Engn, Haikou 570228, Hainan, Peoples R China

2.Chinese Acad Trop Agr Sci, Spice & Beverage Res Inst, Wanning 571533, Peoples R China

3.Chinese Acad Trop Agr Sci, Sanya Res Inst, Sanya 572000, Peoples R China

关键词： Linalool; Shigella sonnei; Membrane damage; Oxidative stress; Enzyme activity

期刊名称：INDUSTRIAL CROPS AND PRODUCTS （ 影响因子：5.9； 五年影响因子：6.0 ）

ISSN： 0926-6690

年卷期： 2023 年 193 卷

页码：

收录情况： SCI

摘要： This work explored the antibacterial mechanism of linalool on Shigella sonnei (S. sonnei) based on membrane damage driven by oxidative stress. The results revealed that linalool had excellent inhibition towards S. sonnei under a concentration of 1.5 mL/L. Furthermore, cell structure was disrupted with massive leakage of K+ and Mg2+ with linalool according to scanning electron microscopy, zeta potential and probes staining of fluorescein diacetate and Rhodamine 123 combined with fluorescence spectroscopy. Changes in membrane protein conformation were also monitored as a result of fluorescence spectroscopy when exposed to linalool. In addition, oxidative stress was appeared after exposure to linalool due to the increase of malondialdehyde, hydrogen peroxide, superoxide anion and oxidized glutathione, and the decrease of reduced glutathione. The activity of defense enzyme including superoxide dismutase, catalase and peroxidase, and antioxidant enzyme including glutathione reductase and glutathione S-transferase was also inhibited. In all, oxidative stress-driven membrane damage was considered as the main mechanism by which linalool inhibited S. sonnei. Our findings provide theoretical support for linalool as a promising natural antibacterial agent against S. sonnei contamination.

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