Piperine Improves DSS-Induced Colitis in Mice via Inhibition of Inflammation and Modulation of Gut Microbiota
文献类型： 外文期刊
作者： Hu, Yeye 1 ; Wang, Yanting 1 ; Gao, Haoyang 1 ; Yang, Guigui 1 ; Xie, Jing 1 ; He, Ziliang 1 ; Lv, Shenghui 3 ; Gu, Fenglin 4 ; Huang, Chaoqing 6 ; Hu, Weicheng 1 ;
作者机构： 1.Yangzhou Univ, Sch Med, Inst Translat Med, Yangzhou, Peoples R China
2.Yangzhou Univ, Key Lab Jiangsu Higher Educ Inst Nucle Acid & Cell, Yangzhou, Peoples R China
3.Guangdong Prov Hosp Tradit Chinese Med, Hainan Hosp, Haikou, Peoples R China
4.Chinese Acad Trop Agr Sci, Spice & Beverage Res Inst, Key Lab Proc Suitabil & Qual Control Special Trop, Hainan, Peoples R China
5.Chinese Acad Trop Agr Sci, Sanya Res Inst, Sanya, Hainan, Peoples R China
6.Jinan Univ, Sch Pharm, Guangzhou, Peoples R China
7.Zhejiang Weikang Pharmaceut Co Ltd, Lishui, Peoples R China
关键词： colitis; fecal microbiota transplantation; gut microbiota; intestinal barrier; Piperine
期刊名称：PHYTOTHERAPY RESEARCH （ 影响因子：6.3； 五年影响因子：7.0 ）
ISSN： 0951-418X
年卷期： 2025 年 39 卷 7 期
页码：
收录情况： SCI
摘要： Inflammatory bowel disease (IBD) is a global health concern with limited therapeutic options. Previous studies have demonstrated that piperine exhibited anti-inflammatory effects both in vitro and in vivo. However, its potential to ameliorate colitis in mice through modulation of gut microbiota has not been explored. This study aimed to investigate the role of gut microbiota in the protective effects of piperine against colitis using a dextran sulfate sodium (DSS)-induced mouse model. Mice were administered piperine (12.5 and 25 mg/kg) prior to DSS exposure. Fecal microbiota transplantation (FMT) was then performed, after which we evaluated colitis symptoms, inflammation levels, and intestinal barrier function. Subsequently, 16S rDNA-based high-throughput sequencing was employed to analyze the microbial composition of the mouse cecal contents. Piperine administration increased the colon length, decreased the spleen index, and improved colon histopathology. Furthermore, piperine modulated inflammatory responses by inhibiting NF-kappa B signaling, thereby reducing the release of pro-inflammatory cytokines and mediators. It also enhanced intestinal barrier integrity by increasing the expression of claudin-1, claudin-3, ZO-1, occludin, and mucin 2. Notably, the 16S rDNA sequencing results revealed that piperine increased the abundance of Dubosiella in the gut. Piperine effectively protected mice from DSS-induced colitis, suppressed inflammation, and improved poor intestinal barrier function. It reshaped the intestinal microbiota, ultimately alleviating DSS-induced colitis in mice. Our research highlighted the significant role of gut microbiota in the piperine-mediated alleviation of intestinal damage and suggested its therapeutic potential for promoting gut health and reducing the risk of colitis.
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