Podophyllotoxin-derived insecticidal agents: Part XIII - Evaluation of insecticidal activity of podophyllotoxin derivatives against Brontispa longissima
文献类型: 外文期刊
作者: Liu, Ying-Qian 1 ; Feng, Gang 3 ; Yang, Liu 4 ; Jing-Zhang 3 ; Li, Hong-Yu 1 ;
作者机构: 1.Lanzhou Univ, Sch Life Sci, MOE Key Lab Arid & Grassland Ecol, Lanzhou 730000, Peoples R China
2.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China
3.Chinese Acad Trop Agr Sci, Environm & Plant Proect Inst, Danzhou 571737, Peoples R China
4.Lanzhou Jiaotong Univ, Environm & Municipal Engn Sch, Lanzhou 730000, Peoples R China
关键词: podophyllotoxin;insecticidal activity;Brontispa longissima;structure-activity relationships
期刊名称:NATURAL PRODUCT RESEARCH ( 影响因子:2.861; 五年影响因子:2.572 )
ISSN: 1478-6419
年卷期: 2011 年 25 卷 16 期
页码:
收录情况: SCI
摘要: In an attempt to find the biorational insecticides for Brontispa longissima control, 12 podophyllotoxin (PPT) analogues were tested for their insecticidal activity against the fifth-instar larvae of B. longissima in vivo for the first time. Among all the tested compounds, especially compounds 6 and 8 showed more promising and pronounced insecticidal activity than toosendanin, a commercial insecticide derived from Melia azedarach. The different insecticidal activity range of compounds 1-12 indicated that the variation of chemical structures in the PPT skeleton markedly affected the activity profiles of this compound class, and some important structure-activity relationship information has been revealed. Together, these preliminary results may be useful in guiding further modification of PPTs in the development of potential new insecticides.
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