Simultaneous Incorporation of 5-Fluorouracil and Leucovorin into Chitosan Nanoparticle as Drug Carrier and Its Characterization
文献类型： 外文期刊
作者： Li, Puwang 1 ; Wang, Yichao 1 ; Peng, Zheng 2 ; Kong, Lingxue 1 ;
作者机构： 1.Deakin Univ, Inst Technol & Res Innovat, Ctr Mat & Fiber Innovat, Geelong, Vic 3217, Australia
2.CATAS, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China
关键词： Colorectal cancer;combined therapy;5-fluorouracil;leucovorin;chitosan nanoparticles
期刊名称：PRICM 7, PTS 1-3 （ 影响因子：0.399； ）
ISSN： 0255-5476
年卷期： 2010 年 654-656 卷
页码：
收录情况： SCI
摘要： A combined drug loaded system containing two most common anti-cancer drugs 5-fluorouracil (5-FU) and leucovorin (LV) was designed and prepared by ion crosslinking technology. The resulted nanoparticles are spherical in shape, and the particle size becomes larger when drug combination are loaded. Efficient drug encapsulation efficiency (EE) and drug loading (LC) are obtained due to the strong interaction between drugs and polymer. The combined drugs are distributed in the particles in amorpholous state which are demonstrated by the XRD results.
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