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A novel antibiotic produced by streptomyces noursei Da07210

文献类型： 外文期刊

作者： Wu, Xiaopeng 1 ; Huang, Huiqin 1 ; Chen, Guangying 2 ; Sun, Qianguang 1 ; Peng, Jie 1 ; Zhu, Jun 1 ; Bao, Shixiang 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Trop Crop Biotechnol, Haikou, Peoples R China

2.Hainan Normal Univ, Dept Chem, Haikou, Peoples R China

关键词： Antifungal activity;Fungicide;Antitumor activity;Actinomycete

期刊名称：ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY （ 影响因子：2.271； 五年影响因子：2.707 ）

ISSN： 0003-6072

年卷期： 2009 年 96 卷 1 期

页码：

收录情况： SCI

摘要： A novel antibiotic 210-A, named as (6S,8aS,9S,11S,12aR)-6-hydroxy-9,10-dimethyldecahydrobenzo[d]azecine-2,4,12(3H)-trione, was isolated from the fermentation broth of Streptomyces noursei Da07210, its structure was unambiguously established by spectral analyses and chemical comparison with related cycloheximide. Experiments demonstrated that 210-A bore strong activity against Fusarium oxysporum f. sp. cubense race four (Foc race four), which also showed antitumor activity against SMMC-7721 human hepatocarcinoma cells and S180 murine sarcoma, and the IC(50) values were 0.77 and 0.74 mu g/ml, respectively.

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