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Synthesis of 4 '-Thiosemicarbazonegriseofulvin and Its Effects on the Control of Enzymatic Browning and Postharvest Disease of Fruits

文献类型： 外文期刊

作者： Pan, Zhi-Zhen 2 ; Zhu, Yu-Jing 2 ; Yu, Xiao-Jie 1 ; Lin, Qi-Fan 1 ; Xiao, Rong-Feng 2 ; Tang, Jian-Yang 2 ; Chen, Qing 1 ;

作者机构： 1.Xiamen Univ, Key Lab, Minist Educ Coastal & Wetland Ecosyst, Sch Life Sci, Xiamen 361005, Peoples R China

2.Fujian Acad Agr Sci, Agr Bioresources Inst, Fuzhou 350003, Peoples R China

关键词： 4 '-thiosemicarbazonegriseofulvin;synthesis;antibrowning activity;antifungal activity;postharvest disease

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

ISSN： 0021-8561

年卷期： 2012 年 60 卷 43 期

页码：

收录情况： SCI

摘要： 4'-Thiosemicarbazonegriseofulvin, a new thiosemicarbazide derivative of griseofulvin, was synthesized and evaluated for its potential in the control of enzymatic browning and postharvest disease of fruits. Browning on fruits is mainly due to the enzymatic oxidation of phenolic compounds catalyzed by tyrosinase. 4'-Thiosemicarbazonegriseofulvin could effectively inhibit the activity of tyrosinase, and its 50% inhibitory concentration (IC50) against tyrosinase was determined to be 37.8 mu M. It was a reversible and noncompetitive inhibitor of tyrosinase, and its inhibition constant (K-I) was determined to be 38.42 mu M. The antifungal activity of 4'-thiosemicarbazonegriseofulvin was studied against four fungi (Fusarium oxysporum, Fusarium moniliforme, Fusariurn solani, and Colletotrichum truncatum) that often cause postharvest diseases of fruits. The results showed that 4'-thiosemicarbazonegriseofulvin could also strongly inhibit the mycelial growth of the four target fungi; the 50% lethal concentration (LC50) values were 5.4, 7.0, 15.3, and 1.5 mM, respectively.

  • 相关文献

[1]Inhibitory Activities of Griseofulvin and Its Analogues against Phytopathogenic Fungi. Zhu, Yu-Jing,Pan, Zhi-Zhen,Su, Ming-Xing,Liu, Bo,Yu, Xiao-Jie,Li, Zhi-Cong,Chen, Qing-Xi,Huang, Jian-Zhong,Wu, Song-Gang.

[2]Identification and genomic analysis of antifungal property of a tomato root endophyte Pseudomonas sp p21. Ma, Rongqin,Cheng, Zhiqiang,Lei, Shaonan,Li, Xin,Tian, Baoyu,Ma, Rongqin,Cheng, Zhiqiang,Lei, Shaonan,Li, Xin,Tian, Baoyu,Cao, Yi,Huang, Wei,Song, Yongkang.

[3]Volatile organic compounds produced by Lysinibacillus sp FJAT-4748 possess antifungal activity against Colletotrichum acutatum. Che, Jianmei,Liu, Bo,Liu, Guohong,Chen, Qianqian,Lan, Jianglin. 2017

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