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Protective effect of Stropharia rugosoannulata polysaccharide and its derivatives on dextran sodium sulfate-induced colitis

文献类型： 外文期刊

作者： Ye, Hongling 1 ; He, Yaling 2 ; Jin, Mingzhi 3 ; Ye, Ziyang 3 ; Huang, Qianli 3 ; Chen, Hui 4 ; Ye, Ming 3 ;

作者机构： 1.Anqing Vocat & Tech Coll, Sch Agr Forestry & Fash Technol, Anqing, Peoples R China

2.Hefei Univ Technol, Instrumental Anal Ctr, Hefei, Peoples R China

3.Hefei Univ Technol, Sch Food & Biol Engn, Hefei 230009, Peoples R China

4.Shanghai Acad Agr Sci, Inst Edible Fungi, Shanghai 201403, Peoples R China

关键词： Anti-inflammatory activity; derivatives; dextran sulfate sodium (DSS)-induced colitis; Stropharia rugosoannulata polysaccharide

期刊名称：FOOD QUALITY AND SAFETY （ 影响因子：4.4； 五年影响因子：4.8 ）

ISSN： 2399-1399

年卷期： 2025 年 9 卷

页码：

收录情况： SCI

摘要： Ulcerative colitis is a common inflammatory bowel disease. This study evaluated the protective effect and potential mechanism of Stropharia rugosoannulata polysaccharide (SP-1a) and its carboxymethylated and phosphorylated derivatives (CSP-1a and PSP-1a) against dextran sulfate sodium (DSS)-induced ulcerative colitis. The results showed that treatment with SP-1a and its derivatives alleviated the symptoms of weight loss, colon shortening, and blood in the stool induced by. SP-1a and its derivatives restore the integrity of the intestinal barrier by controlling the expression of tight junction proteins. Furthermore, they play an anti-inflammatory role by reducing oxidative stress and inhibiting the expression of pro-inflammatory factors, pro-inflammatory proteins, and nuclear factor kappa-B (NF-kappa B) signaling pathways. The anti-inflammatory effects of CSP-1a and PSP-1a were greater than those of SP-1a. These results indicate that SP-1a could be a potential natural medicine to protect against DSS-induced colitis.

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