文献类型： 外文期刊

作者： Garcia-Garcia, Erick ¹ ; Ge, Jun Qing ¹ ; Oladiran, Ayoola ¹ ; Montgomery, Benjamin ¹ ; El-Din, Mohamed Gamal ² ; P ¹ ;

作者机构： 1.Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E9, Canada

2.Univ Alberta, Dept Civil & Environm Engn, Edmonton, AB T6G 2E9, Canada

3.Univ Alberta, Dept Lab Med & Pathol, Edmonton, AB T6G 2E9, Canada

4.Fujian Acad Agr Sci, Inst Biotechnol, Fuzhou 350003, Peoples R China

关键词： Advanced oxidation;Ozone;Immunotoxicity;Water remediation;Water purification;Tailing ponds

期刊名称：WATER RESEARCH （ 影响因子：11.236； 五年影响因子：11.547 ）

ISSN： 0043-1354

年卷期： 2011 年 45 卷 18 期

页码：

收录情况： SCI

摘要： We evaluated whether ozonation ameliorated the effects of the organic fraction of oil sands process water (OSPW) on immune functions of mice. Ozonation of OSPW eliminated the capacity of its organic fraction to affect various mouse bone marrow-derived macrophage (BMDM) functions in vitro. These included the production of nitric oxide and the expression of inducible nitric oxide synthase, the production of reactive oxygen intermediates and the expression of NADPH oxidase subunits, phagocytosis, and the expression of pro-inflammatory cytokine genes. Ozone treatment also eliminated the ability of OSPW organic fraction to down-regulate the expression of various pro-inflammatory cytokine and chemokine genes in the liver of mice, one week after oral exposure. We conclude that ozone treatment may be a valuable process for the remediation of large volumes of OSPW. (C) 2011 Elsevier Ltd. All rights reserved.