Aggregates of octenylsuccinate oat beta-glucan as novel capsules to stabilize curcumin over food processing, storage and digestive fluids and to enhance its bioavailability
文献类型： 外文期刊
作者： Liu, J. 1 ; Lei, L. 1 ; Ye, F. 1 ; Zhou, Y. 1 ; Younis, Heba G. R. 1 ; Zhao, G. 1 ;
作者机构： 1.Southwest Univ, Coll Food Sci, Tiansheng Rd 2, Chongqing 400715, Peoples R China
2.Guizhou Acad Agr Sci, Inst Potato, Guiyang 550006, Guizhou, Peoples R China
3.Chongqing Engn Res Ctr Reg Foods, Chongqing 400715, Peoples R China
期刊名称：FOOD & FUNCTION （ 影响因子：5.396； 五年影响因子：5.534 ）
ISSN： 2042-6496
年卷期： 2018 年 9 卷 1 期
页码：
收录情况： SCI
摘要： Self-aggregates of octenylsuccinate oat beta-glucan (A(OSG)) have been verified as nanocapsules to load curcumin, a representative of hydrophobic phytochemicals. This study primarily investigated the stability of curcumin-loaded A(OSG)s over food processing, storage and digestive fluids. Curcumin in A(OSG)s showed better stability over storage and thermal treatment than its free form. Curcumin loaded in A(OSGs) stored at 4 degrees C in the dark exhibited higher stability than that at higher temperatures or exposed to light. Approximately 18% of curcumin was lost after five freeze-thaw cycles. Curcumin in A(OSG) was more stable than its free form in mimetic intestinal fluids, attesting to the effective protection of A(OSG) for curcumin over digestive environments. When curcumin-loaded A(OSG) travelled across mimetic gastric and intestinal fluids, curcumin was tightly accommodated in the capsule, while it rapidly escaped as the capsule reached the colon. Interestingly, the curcumin loaded in A(OSG) generated higher values of C-max and area under the curve than did its free counterpart. These observations showed that A(OSG) is a powerful vehicle for stabilizing hydrophobic phytochemicals in food processing and storage, facilitating their colontargeted delivery and enhancing their bioavailability.
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