Cadmium exposure induces oxidative stress-mediated necroptosis via TLR4/NF-κB signaling pathway in pig epididymis
文献类型： 外文期刊
作者： Li, Yulong 1 ; Wang, Shu 3 ; Wang, Yanfei 2 ;
作者机构： 1.Qiqihar Univ, Coll Food & Bioengn, Qiqihar 161006, Peoples R China
2.Heilongjiang Acad Agr Sci, Branch Anim Husb & Vet, Qiqihar 161005, Peoples R China
3.Qiqihar Univ, Coll Chem & Chem Engn, Qiqihar 161006, Peoples R China
4.Northeast Agr Univ, Coll Anim Sci & Technol, Harbin 150030, Peoples R China
关键词： Cadmium; Pig epididymis; TLR4/NF-kappa B signaling pathway; Oxidative stress; Necroptosis
期刊名称：ENVIRONMENTAL POLLUTION （ 影响因子：7.3； 五年影响因子：8.1 ）
ISSN： 0269-7491
年卷期： 2025 年 366 卷
页码：
收录情况： SCI
摘要： Cadmium (Cd) can cause reproductive disorders through epididymal injury. However, the specific molecular mechanism of Cd-induced epididymal toxic injury is rarely reported. In this study, the model of Cd poisoning in pig epididymis was established. Ten 6-week-old male piglets were divided into two groups. The control group was fed a basic diet, while the Cd group received a diet supplemented with 20 mg/kg CdCl2. After 40 days, All piglets were euthanized, and epididymal tissues were collected to detect morphological changes, trace element contents, oxidative stress (OS) parameters, toll like receptor 4 (TLR4)/nuclear factor kappa-B (NF-kappa B) signaling pathway and necroptosis marker genes. This study showed that Cd led to an increased concentration of Cd element in pig epididymis. According to morphological observation, pig epididymal tissue in the Cd group was damaged. Cd decreased the contents of glutathione (GSH), total antioxidant capacity (T-AOC), catalase (CAT), dismutase (SOD), and glutathione peroxidase (GSH-px), but the contents of hydrogen peroxide (H2O2) and malondialdehyde (MDA) were increased. Additionally, Caspase 8 expression was decreased, whereas the expression of TLR4, NF-kappa B, FADD, RIPK1, RIPK3, MLKL and heat shock proteins (HSPs) were increased after Cd stimulation. We concluded that Cd-triggered TLR4/NF-kappa B signaling pathway and oxidative stress potentially promoted necroptosis in pig epididymis.
- 相关文献
作者其他论文 更多>>
-
Cadmium Exposure Induces Inflammation Through Oxidative Stress-Mediated Activation of the NF-κB Signaling Pathway and Causes Heat Shock Response in a Piglet Testis
作者：Li, Yulong;Wang, Hongbao;Wang, Yanfei;Li, Yulong
关键词：Cadmium; Piglet testis; Oxidative stress; Inflammation; Heat shock response
-
Cold tolerance SNPs and candidate gene mining in the soybean germination stage based on genome-wide association analysis
作者：Chen, Yuehan;Ma, Qian;Chen, Yuehan;Liu, Zhi;Yang, Qing;Li, Chenhui;Shi, Xiaolei;Zhang, Mengchen;Yang, Chunyan;Yan, Long;Han, Dezhi;Jia, Hongchang;Wang, Shu;Lu, Wencheng;Qiu, Lijuan
关键词：
-
DEVELOPMENT AND TEST OF RICE NITROGEN NUTRITION INDEX ESTIMATION MODEL BASED ON AIRBORNE MULTI-SPECTRUM
作者：Song, Lijuan;Ye, Wanjun;Wang, Shu;Liu, Shubing;Wang, Meixuan;Su, Ge;Bi, Hongwen;Song, Lijuan;Wang, Shu
关键词：Cold-terra rice; Airborne multispectrum; Nitrogen nutrition diagnosis
-
Replacing soybean meal with high-oil pumpkin seed cake in the diet of lactating Holstein dairy cows modulated rumen bacteria and milk fatty acid profile
作者：Li, Yang;Gao, Jianxu;Lv, Jingyi;Lambo, Modinat Tolani;Zhang, Yonggen;Wang, Yanfei;Wang, Liang
关键词：soybean meal; high-oil pumpkin seed cake; rumen bacteria; milk fatty acid profile
-
Selection and evaluation of a set of fingerprint markers for maize in heilongjiang
作者：Guan, Haitao;Wang, Shu;Guan, Haitao;Zhang, Ruiying;Wen, Hongtao;Meng, Qinghong
关键词：
-
Establishment and Application of Critical Nitrogen Dilution Curve for Rice Based on Leaf Dry Matter
作者：Song, Lijuan;Wang, Shu;Song, Lijuan;Ye, Wanjun
关键词：rice; leaf; critical nitrogen dilution curve; nitrogen nutrition index
