Protection against vascular endothelial dysfunction by polyphenols in sea buckthorn berries in rats with hyperlipidemia
文献类型： 外文期刊
作者： Yang, Fang 1 ; Suo, Yourui 1 ; Chen, Dongli 5 ; Tong, Li 2 ;
作者机构： 1.Chinese Acad Sci, Northwest Inst Plateau Biol, 23 Xinning Rd, Xining 810001, Qinghai, Peoples R China
2.Qinghai Univ, Coll Med, Xining, Qinghai, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Qinghai Univ, Qinghai Acad Agr & Forestry Sci, Xining, Qinghai, Peoples R China
5.AA Pharma Inc, Boston, MA USA
关键词： Vascular endothelial dysfunction;polyphenol;sea buckthorn berries;hyperlipidemia;protection
期刊名称：BIOSCIENCE TRENDS （ 影响因子：2.4； 五年影响因子：2.582 ）
ISSN： 1881-7815
年卷期： 2016 年 10 卷 3 期
页码：
收录情况： SCI
摘要： Chronic hyperlipemia increases the incidence of vascular endothelial dysfunction and can even induce cardiovascular disease. Sea buckthorn contains a host of bioactives such as flavonoids and polyphenols that can prevent the development of cardiovascular disease. The current study isolated active ingredients, polyphenols, from sea buckthorn berries (SVP) and orally administered SVP at a dose of 7-28 mg/kg. This treatment significantly reduced serum lipids, it enhanced the activity of antioxidant enzymes, and it decreased the level of serum TNF-alpha and IL-6. SVP also alleviate vascular impairment by decreasing the expression of eNOS, ICAM-1, and LOX-1 mRNA and proteins in aortas of rats with hyperlipidemia. Based on these findings, SVP has antioxidant action and it protects endothelium.
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