文献类型： 外文期刊
作者： Han, Zhuang 1 ; Xu, Ying 1 ; McConnell, Oliver 4 ; Liu, Lingli 1 ; Li, Yongxin 1 ; Qi, Shuhua 2 ; Huang, Xiangzhong 1 ; Q 1 ;
作者机构： 1.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
2.Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,S China Sea Inst, Guangzhou 510301, Guangdong, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
4.John I Haas Inc, Yakima, WA 98902 USA
关键词： marine-derived actinomycete;Streptomyces lusitanus;antibacterial;antimycin B
期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）
ISSN： 1660-3397
年卷期： 2012 年 10 卷 3 期
页码：
收录情况： SCI
摘要： Two new antimycin A analogues, antimycin B1 and B2 (1-2), were isolated from a spent broth of a marine-derived bacterium, Streptomyces lusitanus. The structures of 1 and 2 were established on the basis of spectroscopic analyses and chemical methods. The isolated compounds were tested for their anti-bacterial potency. Compound 1 was found to be inactive against the bacteria Bacillus subtilis, Staphyloccocus aureus, and Loktanella hongkongensis. Compound 2 showed antibacterial activities against S. aureus and L. hongkongensis with MIC values of 32.0 and 8.0 mu g/mL, respectively.
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