Characterization of an Escherichia coli Isolate Coharboring the Virulence Gene astA and Tigecycline Resistance Gene tet(X4) from a Dead Piglet
文献类型： 外文期刊
作者： Wang, Jianmei 1 ; Huang, Yuting 1 ; Guan, Chunjiu 1 ; Li, Jie 4 ; Yang, Hua 1 ; Zhao, Guoping 5 ; Liu, Canying 3 ; Ma, Jiangang 1 ; Tang, Biao 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, Hangzhou 310021, Peoples R China
3.Foshan Univ, Sch Life Sci & Engn, Foshan 528225, Peoples R China
4.Liaocheng Univ, Coll Life Sci, Liaocheng 252000, Peoples R China
5.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Life Sci, Hangzhou 310024, Peoples R China
关键词： Escherichia coli; tet(X4); astA; complete genome sequence
期刊名称：PATHOGENS （ 影响因子：3.7； 五年影响因子：3.7 ）
ISSN：
年卷期： 2023 年 12 卷 7 期
页码：
收录情况： SCI
摘要： tet(X4) is the critical resistance gene for tigecycline degradation that has been continually reported in recent years. In particular, pathogenic bacteria carrying tet(X4) are a severe threat to human health. However, information describing Escherichia coli coharboring tet(X4) with virulence genes is limited. Here, we isolated an E. coli strain coharboring tet(X4) and the heat-stable toxin gene astA from a dead piglet. The strain named 812A1-131 belongs to ST10. The genome was sequenced using the Nanopore and Illumina platforms. The virulence genes astA and tet(X4) are located on the chromosome and in the IncHI1-type plasmid p812A1-tetX4-193K, respectively. The plasmid could be conjugatively transferred to recipient E. coli J53 with high frequency. In vivo experiments showed that strain 812A1-131 is pathogenic to Galleria mellonella and could colonize the intestines of mice. In summary, pathogenic E. coli could receive a plasmid harboring the tet(X4) gene, which can increase the difficulty of treatment. The prevalence and transmission mechanisms of pathogenic bacteria coharboring the tet(X4) gene need more attention.
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