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Synthesis and characterization of carboxymethyl chitosan/epoxidized soybean oil based conjugate catalyed by UV light, and its application as drug carrier for fusarium wilt

文献类型： 外文期刊

作者： Zhou, Chuang 1 ; Zhang, Li 2 ; Yang, Ziming 1 ; Pan, Qingyan 1 ; He, Zuyu 1 ; Wang, Chao 1 ; Liu, Yunhao 1 ; Song, Shuhui 1 ; Yang, Zhuohong 3 ; Chen, Yu 4 ; Li, Puwang 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, South Subtrop Crop Res Inst, Key Lab Hainan Prov Postharvest Physiol & Technol, Zhanjiang 524091, Peoples R China

2.Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Key Lab Trop Crop Prod Proc Minist Agr & Rural Aff, Zhanjiang 524001, Peoples R China

3.South China Agr Univ, Coll Mat & Energy, Guangzhou 510642, Peoples R China

4.Beijing Inst Technol, Sch Mat Sci & Engn, Beijing 100081, Peoples R China

关键词： Photo-chemical reactions; Microcapsules; Antifungal

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.025； 五年影响因子：7.626 ）

ISSN： 0141-8130

年卷期： 2022 年 212 卷

页码：

收录情况： SCI

摘要： In this paper, a cationic photoinitiator (TAS) was used as a catalyst for the ring opening reaction of carboxymethyl chitosan (CMCS) and epoxidized soybean oil (ESO) under UV light to prepare CMCS-g-ESO conjugate, and the structure of the product was characterized by FT-IR, 1H NMR and GPC. Then, the spinosad-loaded microcapsules (SSD@CMCS-g-ESO) were prepared by ultrasonic self-assembly method. The results showed that TAS could catalyze the ring opening reaction of CMCS and ESO under UV-irradiation and the optimum reaction time was 1 h, with the molecular weight of 15,745. The average particle size of SSD@CMCS-g-ESO was about 2.16 mu m, and the encapsulation efficiency (EE) and drug loading content (LC) of SSD@CMCS-g-ESO were 85.39 & PLUSMN; 2.05% and 20.17 +/- 1.84%, respectively. In vitro release revealed that SSD@CMCS-g-ESO exhibited sustained-release and pH-responsive property, and the accumulative release in the buffer solution of pH = 6.5 and 7.4 was higher than in pH = 9.0. Furthermore, SSD@CMCS-g-ESO had a good antifungal properties against Fusarium oxysporum f. sp. cubense (Foc) compared with the unencapsulated SSD at the same drug dose. This work indicated that photo-chemical reactions could be used to prepare bio-based carrier materials to construct drugs delivery system for targeted treatment of fusarium wilt.

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