您好,欢迎访问中国水产科学研究院 机构知识库!

Genome-wide characterization of caspase genes in Japanese pufferfish, Takifugu rubripes, and expression profiles in response to Vibrio harveyi infection

文献类型: 外文期刊

作者: Yang, Xu 1 ; Liu, Xia 1 ; Yang, Zhen 1 ; Guan, Yude 1 ; Zhao, Ruihu 1 ; Peng, Hongyu 1 ; Cao, Xinyu 1 ; Gao, Minghong 1 ; Wang, Shuhui 1 ; Jiang, Chen 1 ;

作者机构: 1.Dalian Ocean Univ, Key Lab Mariculture & Stock Enhancement North Chi, Minist Agr, Dalian, Peoples R China

2.Chinese Acad Fishery Sci, Hebei Key Lab Bohai Sea Fish Germplasm Resources, Beidaihe Cent Expt Stn, Qinhuangdao, Hebei, Peoples R China

关键词: caspase; expression profiles; Japanese pufferfish; Vibrio harveyi

期刊名称:JOURNAL OF THE WORLD AQUACULTURE SOCIETY ( 影响因子:3.402; 五年影响因子:2.934 )

ISSN: 0893-8849

年卷期:

页码:

收录情况: SCI

摘要: Caspases, also known as cysteine-dependent aspartate-directed proteases, play an important role in regulating apoptosis during development and inflammation. In this study, 10 caspase genes were characterized by searching the Japanese pufferfish genome using various bioinformatics methods, such as multiple sequence alignment and phylogenetic analysis. Additionally, we characterized the caspase genes and examined the expression profiles of every member in both healthy tissues and tissues infected with Vibrio harveyi in the liver and intestine. Our results revealed that 10 caspase genes were detected in all examined tissues, and the expression levels varied among different tissues and genes. Vibrio harveyi infection induced significant changes in the expression of 10 caspases in a time-dependent manner, suggesting that they might play key roles in the defense process of Japanese pufferfish. Our findings offer strong support for future studies aiming to provide an initial assessment of caspase genes in teleosts.

  • 相关文献
作者其他论文 更多>>