您好，欢迎访问广东省农业科学院 机构知识库！
广东省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Cinnamon free phenolic extract regulates glucose absorption in intestinal cells by inhibiting glucose transporters

文献类型： 外文期刊

作者： Liu, Yaoyao 1 ; Pang, Daorui 1 ; Xing, Dongxu 1 ; Wang, Weifei 1 ; Li, Qian 1 ; Liao, Sentai 1 ; Li, Erna 1 ; Zou, Yuxiao 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, Key Lab Funct Foods,Minist Agr & Rural Affairs, Guangdong Key Lab Agr Prod Proc, Guangzhou 510610, Guangdong, Peoples R China

关键词： Cinnamon free phenolic extract; Glucose uptake and transport; SGLT1; GLUT2

期刊名称：FOOD BIOSCIENCE （ 影响因子：5.2； 五年影响因子：5.4 ）

ISSN： 2212-4292

年卷期： 2023 年 52 卷

页码：

收录情况： SCI

摘要： Cinnamon is a traditional herbal medicine that is a valuable source of bioactive phenolic compounds. In this study, we determined the effects of cinnamon free phenolic extract (CFPE) on glucose transport in Caco-2 cells and its possible mechanisms of action. First, the contents of phenolic compounds and flavonoids in bark were compared among four cinnamon cultivars. The 'Taiwan' cultivar had the highest contents of these compounds, and the CFPE was prepared from it. A Caco-2 monolayer was established, and the effect of CFPE on glucose transport across the monolayer was determined. The results showed that CFPE (at 150-300 mu g/mL) suppressed glucose transport across the monolayer in a dose-dependent manner. Procyanidin C1, procyanidin B2, procya-nidin B1, procyanidin B3, procyanidin A2, and (-)-epicatechin derivatives in CFPE may have contributed to its suppressive effect. Treatment with CFPE decreased the transcript levels of SGK1 encoding serum and glucocorticoid-inducible kinase and PLC/PKC encoding phospholipase C/protein kinase C, which are involved in the signaling pathway associated with glucose transport; and the transcript levels of SGLT1 encoding sodium/ glucose cotransporter 1 and GLUT2 encoding glucose transporter 2, the key glucose transporters in this pathway. These findings suggest that CFPE inhibits glucose transport via its effects on the signaling pathway and glucose transporters involved in glucose absorption in intestinal cells. Thus, CFPE has potential applications in pre-venting postprandial hyperglycemia.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：广东省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台