Grid Computing Simulations of Ion Channel Block Effects on the ECG Using 3D Anatomically-Based Models
文献类型： 会议论文
第一作者： M. O. Bernabeu
作者： M. O. Bernabeu 1 ; A. Corrias 1 ; J. Pitt-Francis 1 ; B. Rodriguez 1 ; B. Bethwaite 2 ; C. Enticott 2 ; S. Garic 2 ; T. Peachey 3 ; J. Tan 2 ; D. Abramson 2 ; D. Gavaghan 1 ;
作者机构： 1.Computing Laboratory. University of Oxford
2.MESSAGE Laboratory Caulfield. School of Information Technology, Monash University
3.MESSAGE Laboratory Caulfield. School of Information Technology, MonashUniversity
会议名称： Annual Computers in Cardiology Conference
主办单位：
页码： 213-216
摘要： In this study, a computational framework combining state-of-the-art cardiac simulation software and Grid computing is used to investigate the impact of the block of the HERG current on the ECG waveform using state-of-the-art 3D ventricular models of electrophysiology. The technology developed enables (i) automated parameter sweeping using multiscale models (from ion channel to ECG) and (ii) reduced execution time of the simulations performed.
分类号： TP399-53
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