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CHROMATOGRAPHIC STRATEGY IN BIOPRODUCT PURIFICATION

文献类型: 会议论文

第一作者: J. H. Creedy

作者: J. H. Creedy 1 ;

作者机构: 1.TosoHaas GmbH Zettachring 6 D-70567 Stuttgart GERMANY

会议名称: Progress in ion exchange :

主办单位:

页码: 219-226

摘要: The isolation of natural products, especially proteins, peptides, and other macromolecular species from biological source material presents a number of unique problems to the purification chemist. Such material is characteristically complex and many contaminants are similar in nature to the target product. A number of well-established purification modes are available, including Ion Exchange, Hydrophobic Interaction and Size Exclusion chromatography, together with an array of alternative resins representing each mode. It is common for several sequential stages and complementary modes to be required for effective purification of a protein product. Selection of the most suitable resin, however, and its implementation within a purification strategy can be a daunting proposition.

分类号: O647.31

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