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Mapping the distance between the brain and the inner surfaceof the skull and their global asymmetries

文献类型: 会议论文

第一作者: Marc Fournier

作者: Marc Fournier 1 ; Benoit Combes 1 ; Neil Roberts 2 ; Jose Braga 3 ; Sylvain Prima 1 ;

作者机构: 1.INSERM, IRISA-INRIA VisAGeS Project-Team, F-35042 Rennes, France

2.CRIC, Queen's Medical Research Institute, Edinburgh, U.K

3.AMIS, Paul Sabatier University, Toulouse, France

关键词: Brain-skull MRI segmentation;Brain-skull relations;Surface-based brain hull;Brain-endocast distance;Brain asymmetry;Endocranial asymmetry;Average brain-endocast shapes;Brain-endocast asymmetry t-test

会议名称: SPIE Conference on Image processing

主办单位:

页码: 79620Y:1-79620Y:7

摘要: The primary goal of this paper is to describe i) the pattern of pointwise distances between the human brain (pial surface) and the inner surface of the skull (endocast) and ii) the pattern of pointwise bilateral asymmetries of these two structures. We use a database of MR images to segment meshes representing the outer surface of the brain and the endocast. We propose automated computational techniques to assess the endocast-to-brain distances and endocast-and-brain asymmetries, based on a simplified yet accurate representation of the brain surface, that we call the brain hull. We compute two meshes representing the mean endocast and the mean brain hull to assess the two patterns in a population of normal controls. The results show i) a pattern of endocast-to-brain distances which are symmetrically distributed with respect to the mid-sagittal plane and ii) a pattern of global endocast and brain hull asymmetries which are consistent with the well-known Yakovlevian torque. Our study is a first step to validate the endocranial surface as a surrogate for the brain in fossil studies, where a key question is to elucidate the evolutionary origins of the brain torque. It also offers some insights into the normal configuration of the brain/skull interface, which could be useful in medical imaging studies (e.g. understanding atrophy in neurodegenerative diseases or modeling the brain shift in neurosurgery).

分类号: N-532

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