Anti-inflammatory and Angiotensin I-Converting Enzyme Inhibitory of Malvidin and its Glycosides from Vaccinium Ashei
文献类型： 会议论文
第一作者： Han WU
作者： Han WU 1 ; Zheng YAN 1 ; Wu-yang HUANG 1 ;
作者机构： 1.Institute of Farm Product Processing, Jiangsu Academy of Agricultural Sciences
关键词： Blueberry;Malvidin and glycosides;Anti-inflammation;ACE inhibitor;Endothelial cells
会议名称： International Conference on Biological Sciences and Technology
主办单位：
页码： 208-216
摘要： Protective effects of malvidin and the glycosides from Vaccinium ashei on endothelial cells were investigated. The results showed that malvidin, malvidin-3-glucoside, malvidin-3-galactoside, and their mixture could defend endothelial cells from damage caused by TNF-a, and inhibit monocyte chemotactic protein-1, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and angiotensin I-converting enzyme expression. In addition, they could inhibit degradation of IκBα and obstruct the nuclear translocation of p65, suggesting the anti-inflammatory mechanism of NF-κB pathway. The results indicated blueberry anthocyanins could be potential inflammation and ACE inhibitors, and blueberry could be functional foods advantageous to maintain a healthy cardiovascular population.
分类号： Q81-53
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