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Production of IgM by B Cells After Stimulation with GLIS from Ganoderma lucidum Mushroom

文献类型: 会议论文

第一作者: QINGJIU TANG

作者: QINGJIU TANG 1 ; JINGSONG ZHANG; WERNER REUTTER; HUA FAN; Shanghai Academy of Agricultural Sciences(SAAS); Shanghai Academy of Agricultural Sciences(SAAS);;

作者机构: 1.Edible Fungi Institute, Shanghai Academy of Agricultural Sciences, Shanghai, 201106, China

关键词: ganoderma lucidum;GLIS;IgM;macrophages;B cells

会议名称: ACTA Edulis Fungi 2005 vol.12 Supplement:Proceedings of the Fifth International Conference on Mushroom Biology and Mushroom Products

主办单位:

页码: 535-541

摘要: Ganoderma lucidum, a traditional Chinese medicine, harbors a well-known capacity to modulate immunoactivity and inhibit tumour cell growth. GLIS is a proteoglycan fraction purified from G. lucidum through different chromatographic steps. This fraction has been proven to induce the proliferation and differentiation of lymphocytes and activation of macrophages. In the presence of GLIS, B cells were activated into antibody producing plasma cells, and secreted significant amounts of IgM. With respect to the response to mouse spleen lymphocytes (MSLs), the relative amount of IgM obtained from B cells induced with GLIS was lower in the absence of accessory cells. When 0.5% macrophages (0.5%) were added to B cells, B cell survival and IgM secretion increased significantly after stimulation with GLIS. The interaction of B cells and macrophages was not due only to the substances secreted by macrophages, but also to a direct effect.

分类号: S646

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