1Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain

作者： Peng, Yinghua; Peng, Yinghua; Wang, Xiaohui; Zhang, Xiaozheng; Zhang, Tianshu; Li, Hongyuan; Wang, Yibo; Li, Hang; Chen, Hongqian; Wang, Xiaohui; Grace, Peter M.; Watkins, Linda R.; Grace, Peter M.; Watkins, Linda R.; Hutchinson, Mark R.; Hutchinson, Mark R.; Yin, Hang; Wang, Xiaohui; SCI

机构： Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, State Key Lab Mol Biol Special Econ Anim, Changchun 130112, Jilin, Peoples R China; Yantai Univ, Minist Educ, Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Peoples R China; Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China; Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA; Univ Colorado, Ctr Neurosci, Boulder, CO 80309 USA; Univ Adelaide, Adelaide Med Sch, Discipline Physiol, Adelaide, SA, Australia; Univ Adelaide, ARC Ctr Excellence Nanoscale Biophoton, Adelaide, SA 5000, Australia; Tsinghua Univ, Tsinghua Univ Peking Univ Joint Ctr Life Sci, Sch Pharmaceut Sci, Beijing 100082, Peoples R China; Univ Sci & Technol China, Dept Appl Chem & Engn, Hefei 230026, Anhui, Peoples R China;

来源：BRAIN BEHAVIOR AND IMMUNITY

关键词： Toll-like receptor 4; Myeloid differentiation protein 2; Rats; Microglia; NFkB; Proinflammatory cytokines; CD11b; Allodynia

年份：2019

2Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling

作者： Zhang, Xiaozheng; Wang, Yibo; Zhang, Tianshu; Wu, Siru; Wang, Xiaohui; Zhang, Xiaozheng; Wang, Yibo; Zhang, Tianshu; Wu, Siru; Wang, Xiaohui; Zhang, Xiaozheng; Wang, Xiaohui; Peng, Yinghua; Grace, Peter M.; Kwilasz, Andrew J.; Watkins, Linda R.; Metcalf, Matthew D.; Portoghese, Philip S.; Selfridge, Brandon R.; Rice, Kenner C.; Selfridge, Brandon R.; Rice, Kenner C.; Hutchinson, Mark R.; Hutchinson, Mark R.; Wang, Xiaohui; SCI

机构： Chinese Acad Sci, Changchun Inst Appl Chem, Biol Chem Lab, Changchun, Jilin, Peoples R China; Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing, Jiangsu, Peoples R China; Univ Chinese Acad Sci, Beijing, Peoples R China; Chinese Acad Agr Sci, Inst Special Wild Econ Anim & Plants, State Key Lab Mol Biol Special Econ Anim, Changchun, Jilin, Peoples R China; Univ Colorado Boulder, Dept Psychol & Neurosci, Ctr Neurosci, Boulder, CO USA; Univ Minnesota, Coll Pharm, Dept Med Chem, Minneapolis, MN 55455 USA; NIDA, Drug Design & Synth Sect, Bethesda, MD 20892 USA; NIAAA, Bethesda, MD USA; Univ Adelaide, Discipline Physiol, Adelaide Med Sch, Adelaide, SA, Australia; Univ Adelaide, Australian Res Council ARC, Ctr Excellence Nanoscale Biophoton, Adelaide, SA, Australia; Univ Sci & Technol China, Dept Appl Chem & Engn, Hefei, Anhui, Peoples R China;

来源：FASEB JOURNAL

关键词： norbinaltorphimine; enantioselective modulation; TLR4; MD-2; morphine analgesia

年份：2019

3Targeting trimeric transmembrane domain 5 of oncogenic latent membrane protein 1 using a computationally designed peptide

作者： Wang, Yibo; Zhang, Bo; Zhang, Xiaozheng; Li, Hongyuan; Wang, Xiaohui; Wang, Yibo; Peng, Yinghua; Wilson, Andrew J.; Wilson, Andrew J.; Mineev, Konstantin S.; Wang, Xiaohui; SCI

机构： Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China; Sun Yat Sen Univ, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China; Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, State Key Lab Mol Biol Special Wild Econ Anim, Changchun 130112, Jilin, Peoples R China; Univ Leeds, Sch Chem, Woodhouse Lane, Leeds LS2 9JT, W Yorkshire, England; Univ Leeds, Astbuty Ctr Struct Mol Biol, Woodhouse Lane, Leeds LS2 9JT, W Yorkshire, England; Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia; Univ Sci & Technol China, Dept Appl Chem & Engn, Hefei 230026, Anhui, Peoples R China;

来源：CHEMICAL SCIENCE

年份：2019

4Dissecting the Innate Immune Recognition of Opioid Inactive Isomer (+)-Naltrexone Derived Toll-like Receptor 4 (TLR4) Antagonists

作者： Zhang, Xiaozheng; Chen, Hongqian; Zhang, Tianshu; Wang, Yibo; Wang, Xiaohui; Zhang, Xiaozheng; Yang, Kecheng; Zhang, Xiaozheng; Cui, Fengchao; Yang, Kecheng; Li, Yunqi; Jiang, Zhenyan; Rice, Kenner C.; Rice, Kenner C.; Watkins, Linda R.; Watkins, Linda R.; Hutchinson, Mark R.; Hutchinson, Mark R.; Peng, Yinghua; SCI

机构： Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China; Univ Chinese Acad Sci, Beijing 100039, Peoples R China; China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China; Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Synthet Rubber, Changchun 130022, Jilin, Peoples R China; Jilin Univ, Sch Pharmaceut Sci, Changchun 130021, Jilin, Peoples R China; NIDA, Drug Design & Synth Sect, Rockville, MD 20892 USA; NIAAA, NIH, Rockville, MD 20892 USA; Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA; Univ Colorado, Ctr Neurosci, Boulder, CO 80309 USA; Univ Adelaide, Adelaide Med Sch, Discipline Physiol, Adelaide, SA 5005, Australia; Univ Adelaide, ARC Ctr Excellence Nanoscale Biophoton, Adelaide, SA 5005, Australia; Chinese Acad Agr Sci, Inst Special Wild Econ Anim & Plants, State Key Lab Mol Biol Special Econ Anim, Changchun 130112, Jilin, Peoples R China;

来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING

年份：2018

5Nicotine and its metabolite cotinine target MD2 and inhibit TLR4 signaling

作者： Li, Hongyuan; Lin, Cong; Zhang, Xiaozheng; Zhang, Tianshu; Wang, Yibo; Li, Yuanpeng; Wu, Siru; Wang, Hongshuang; Wang, Xiaohui; Peng, Yinghua; Hutchinson, Mark R.; Watkins, Linda R.; Watkins, Linda R.; Wang, Xiaohui; Hutchinson, Mark R.; SCI

机构： Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China; Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, Changchun 130112, Jilin, Peoples R China; Univ Adelaide, Adelaide Med Sch, Discipline Physiol, Adelaide, SA, Australia; Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA; Univ Colorado, Ctr Neurosci, Boulder, CO 80309 USA; Univ Sci & Technol China, Dept Appl Chem & Engn, Hefei 230026, Peoples R China; Univ Adelaide, ARC Ctr Excellence Nanoscale Biophoton, Adelaide, SA 5000, Australia;

来源：INNOVATION

关键词： nicotine; cotinine; Toll-like receptor 4; myeloid differentiation protein 2; microglia; molecular dynamics simulation

年份：2021

6Cannabidiol Analogue CIAC001 for the Treatment of Morphine-Induced Addiction by Targeting PKM2

作者： Jin, Sha; Lu, Yuyuan; Wang, Xiaohui; Jin, Sha; Lin, Cong; Wang, Yibo; Wang, Hongshuang; Wang, Xiaohui; Jin, Sha; Lu, Yuyuan; Wen, Xin; Xiao, Peng; Sun, Jinpeng; Li, Xiaodong; Peng, Yinghua; Wang, Xiaohui; SCI

机构： Univ Sci & Technol China, Sch Appl Chem & Engn, Hefei 230026, Anhui, Peoples R China; Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China; Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China; Shandong Univ, Cheeloo Coll Med, Sch Basic Med Sci, Dept Biochem & Mol Biol,Key Lab Expt Teratol,Minis, Jinan 250012, Shandong, Peoples R China; Beijing Changping Huayou Hosp, Beijing 102299, Peoples R China; Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, State Key Lab Mol Biol Special Econ Anim, Changchun 130112, Jilin, Peoples R China; Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China;

来源：JOURNAL OF MEDICINAL CHEMISTRY

年份：2023

7Cannabidiol alleviates neuroinflammation and attenuates neuropathic pain via targeting FKBP5

作者： Wang, Xue; Wang, Xue; Wang, Xiaohui; Lin, Cong; Jin, Sha; Wang, Yibo; Wang, Xiaohui; Jin, Sha; Wang, Xiaohui; Peng, Yinghua; Wang, Xiaohui; Wang, Xiaohui; SCI

机构： First Hosp Jilin Univ, Dept Anesthesiol, Lequn Branch, Changchun 130021, Peoples R China; Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China; Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Peoples R China; Univ Sci & Technol China, Sch Appl Chem & Engn, Hefei 230026, Peoples R China; Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, Key Lab Mol Biol Special Econ Anim, Changchun 130112, Peoples R China; Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China; Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun, Peoples R China;

来源：BRAIN BEHAVIOR AND IMMUNITY

关键词： Cannabidiol; FKBP5; NF-xB; Neuroinflammation; Neuropathic pain

年份：2023

8Artemisinin inhibits TLR4 signaling by targeting co-receptor MD2 in microglial BV-2 cells and prevents lipopolysaccharide-induced blood-brain barrier leakage in mice

作者： Zhang, Tianshu; Zhang, Xiaozheng; Lin, Cong; Wu, Siru; Wang, Fanfan; Wang, Hongshuang; Wang, Yibo; Li, Hongyuan; Wang, Xiaohui; Zhang, Tianshu; Wang, Fanfan; Peng, Yinghua; Hutchinson, Mark R.; Hutchinson, Mark R.; Wang, Xiaohui; SCI

机构： Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China; Yantai Univ, Minist Educ, Key Lab Mol Pharmacol & Drug Evaluat, Yantai, Peoples R China; Normal Univ, Sch Chem & Pharmaceut Sci Guangxi, State Key Lab Chem & Mol Engn Med Resources, Guilin, Peoples R China; Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, State Key Lab Mol Biol Special Econ Anim, Changchun, Jilin, Peoples R China; Univ Adelaide, Adelaide Med Sch, Discipline Physiol, Adelaide, SA, Australia; Univ Adelaide, ARC Ctr Excellence Nanoscale Biophoton, Adelaide, SA, Australia; Univ Sci & Technol China, Dept Appl Chem & Engn, Hefei, Peoples R China;

来源：JOURNAL OF NEUROCHEMISTRY

关键词： artemisinin; blood-brain barrier; microglia; myeloid differentiation protein 2; Toll-like receptor

年份：2021

9Exploring Methamphetamine Nonenantioselectively Targeting Toll-like Receptor 4/Myeloid Differentiation Protein 2 by in Silico Simulations and Wet-Lab Techniques

作者： Zhang, Xiaozheng; Wang, Yibo; Wang, Hongshuang; Li, Hongyuan; Zhang, Tianshu; Wang, Xiaohui; Wang, Xiaohui; Peng, Yinghua; SCI

机构： Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Peoples R China; Univ Sci & Technol China, Dept Appl Chem & Engn, Hefei 230026, Peoples R China; Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, State Key Lab Mol Biol Special Econ Anim, Changchun 130112, Peoples R China;

来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING

年份：2020

10Dissecting Role of Charged Residue from Transmembrane Domain 5 of Latent Membrane Protein 1 via In Silico Simulations and Wet-Lab Experiments

作者： Wang, Yibo; Zhang, Bo; Lin, Cong; Wang, Xiaohui; Zhang, Bo; Wang, Xiaohui; Liu, Ying; Yang, Min; Peng, Yinghua; SCI

机构： Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China; Univ Sci & Technol China, Dept Appl Chem & Engn, Hefei 230026, Anhui, Peoples R China; Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, State Key Lab Mol Biol Special Econ Anim, Changchun 130112, Jilin, Peoples R China;

来源：JOURNAL OF PHYSICAL CHEMISTRY B

年份：2021